Effect of Fagonia cretica Linn Ethanolic Extract on Many Biochemical Parameters in Albino Rats in Sudan

TLDR: The study targeted to determine the effects of ethanolic extracts of Fagonia cretica linn plant on many biochemical parameters in Albino rats Khartoum, Omdurman, and Shendi towns in Sudan during January – February, 2011.

Abstract: The study targeted to determine the effects of ethanolic extracts of Fagonia cretica linn plant on many biochemical parameters in Albino rats Khartoum, Omdurman, and Shendi towns in Sudan during January – February, 2011. To determine the medicinal properties of the plant and to study the effects of the plant on many biochemical parameters. Different methods were adopted to achieve the objectives of this study, including Harborne methods for extraction. A total of 30 young adult Wistar rats, of age of 8-12 weeks were obtained from the Sudan National Centre for Research, Khartoum Sudan. These rats were divided into 4 groups, three groups are study groups ,where the 4th group was control group. The rats were fed standard rat food and water d libitum, were maintained at standard laboratory conditions. Ethical approval had been obtained from Omdurman Islamic University, Faculty of Pharmacy, and department of Pharmacology, under the number (01/0/2013) .Before the experiment was beginning; rats were fasted overnight for 14 – 16 hours. Group C, which was the control group, received 10 ml/kg body wt. distilled water, orally, throughout the study period while Groups 1, 2 and 3 were orally administered single, daily doses, 100, 300 and 600 mg/kg of body weight, respectively of the Fagonia cretica ethanolic extract dissolved in distilled water 1gm/10ml for 14 days using acute oral toxicity 425 protocol.