Effect of macronutrient deficiency on withanolides content in the roots of Withania somnifera and its correlationship with molybdenum content
Santosh T Devkar,Sanket M Suryapujary,Suresh Jagtap,Surendra S. Katyare,Mahabaleshwar V. Hegde +4 more
TLDR
It was observed that nitrogen metabolism-dependent molybdenum uptake influences the withanolides accumulation in the roots of W. somnifera.Abstract:
Context: The content of withanolides in the roots of Withania somnifera (L.) Dunal (Solanaceae) is important for therapeutic application. Earlier studies have shown that the deficiency of macro- and micronutrients affects the growth of W. somnifera. Therefore, we examined the effect of these deficiencies on the withanolides content of the roots.Objective: To examine the effect of molybdenum accretion in nitrogen-, phosphorus-, calcium- and potassium-deficient soils on the accumulation of withanolides in the roots of W. somnifera. Different withanolides have different therapeutic applications hence major bioactive withanolides assume importance.Materials and methods: Methanol extracts of the roots were subjected to HPTLC and individual withanolides were identified by comparing their Rf values with those of the authentic samples. Molybdenum was quantified by atomic absorption spectroscopy. Free radical scavenging activity was monitored by the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay.Results: Moly...read more
Citations
More filters
Journal ArticleDOI
A WRKY transcription factor from Withania somnifera regulates triterpenoid withanolide accumulation and biotic stress tolerance through modulation of phytosterol and defense pathways
Anup Kumar Singh,Sarma Rajeev Kumar,Varun Dwivedi,Avanish Rai,Shaifali Pal,Ajit Kumar Shasany,Dinesh A. Nagegowda +6 more
TL;DR: While WsWRKY1 silencing in W. somnifera compromised the tolerance to bacterial growth, fungal infection, and insect feeding, its overexpression in tobacco led to improved biotic stress tolerance, demonstrating its importance as a metabolic engineering tool for simultaneous improvement of triterpenoid biosynthesis and plant defense.
Journal ArticleDOI
Evaluation of the bioavailability of major withanolides of Withania somnifera using an in vitro absorption model system.
Santosh T Devkar,Amit D. Kandhare,Brian D Sloley,Suresh Jagtap,James Lin,Yun K Tam,Surendra S. Katyare,Subhash L. Bodhankar,Mahabaleshwar V. Hegde +8 more
TL;DR: Surprisingly and paradoxically, the highly biologically active withaferin A was completely impermeable, suggesting that further studies possibly using human epithelial colorectal adenocarcinoma (Caco-2) cells may be needed to delineate the absorption characteristics of withanolides, especially withafer in A.
Journal ArticleDOI
Nutritional Composition, Bioactive Compounds, and Volatiles Profile Characterization of Two Edible Undervalued Plants: Portulaca oleracea L. and Porophyllum ruderale (Jacq.) Cass
TL;DR: In this paper , quality characteristics were typified in Portulaca oleracea L. and Porophyllum ruderale (Jacq.) Cass, undervalued plants inherent to the spring-summer season in the Valencian coastal region.
References
More filters
Book
The Nature and Properties of Soils
Nyle C. Brady,Ray R. Weil +1 more
TL;DR: The Soils Around Us 2 Formation of Soils from Parent Materials 3 Soil Classification 4 Soil Architecture and Physical Properties 5 Soil Water: Characteristics and Behavior 6 Soil and the Hydrologic Cycle 7 Soil Aeration and Temperature 8 Soil Colloids: Seat of Soil Chemical and Physical Activity 9 Soil Acidity 10 Soils of Dry Regions: Alkalinity, Salinity, and Sodicity 11 Organisms and Ecology of the Soil 12 Soil Organic Matter 13 Nitrogen and Sulfur Economy of Soiles 14 Soil Ph
Journal ArticleDOI
Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion
TL;DR: In this paper, the autoxidation of soybean oil in a cyclodextrin emulsion system was studied in the presence of an emulsion stabilizer consisting of polysaccharides such as xanthan, tragacanth gum, and methylcellulose.
Journal Article
Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.
TL;DR: Preliminary studies have found various constituents of ashwagandha exhibit a variety of therapeutic effects with little or no associated toxicity, indicating this herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects.
Journal ArticleDOI
Steroidal lactones from Withania somnifera, an ancient plant for novel medicine.
TL;DR: An overview of the chemical structures of triterpenoid components and their biological activity is presented, focusing on two novel activities, tumor inhibition and antiangiogenic properties of withaferin A and the effects of withanolide A on Alzheimer's disease.