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Effect of transcutaneous electrotherapy on CSF β-endorphin content in patients without pain problems

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TLDR
In this article, the authors measured β-endorphin cerebrospinal fluid (CSF) content in 13 patients without pain problems and found a time dependent increase of CSF β endorphin in the group of patients studied.
Abstract
To test the hypothesis of opiate-like peptide release after transcutaneous electrotherapy we measured β-endorphin cerebrospinal fluid (CSF) content in 13 patients without pain problems. The results indicate a time dependent increase of CSF β-endorphin in the group of patients studied. This fact suggests that the analgesic properties of the treatment may be ascribed to an involvement of the endogenous opiates system, independently from the basal clinical conditions of the patients.

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Citations
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Repetitive training of isolated movements improves the outcome of motor rehabilitation of the centrally paretic hand

TL;DR: The results of the present study emphasize the importance of frequent movement repetition for the motor rehabilitation of the centrally paretic hand and challenge conventional physiotherapeutic strategies that focus on spasticity reduction instead of early initiation of active movements.
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Transcutaneous electrical nerve stimulation: Basic science mechanisms and clinical effectiveness

TL;DR: TENS is a noninvasive modality that is easy to apply with relatively few contraindications, however, the clinical efficacy of TENS will remain equivocal until the publication of sufficient numbers of high quality, randomized, controlled clinical trials.
Journal Article

Blockade of Opioid Receptors in Rostral Ventral Medulla Prevents Antihyperalgesia Produced by Transcutaneous Electrical Nerve Stimulation (TENS)

TL;DR: Low-frequency and high-frequency TENS produces antihyperalgesia by activation of mu- and delta-opioid receptors, respectively, in the RVM, and the dose of naloxone and naltrindole used in the current study blocks mu-
Journal Article

Spinal Blockade of Opioid Receptors Prevents the Analgesia Produced by TENS in Arthritic Rats

TL;DR: This study investigated the role of mu, delta, and kappa opioid receptors in antihyperalgesia produced by low- and high-frequency TENS by using an animal model of inflammation to address the neurophysiological basis for the actions of TENS.
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Transcutaneous electrical nerve stimulation (TENS) versus placebo for chronic low-back pain.

TL;DR: There was conflicting evidence about whether TENS was beneficial in reducing back pain intensity and consistent evidence in two trials that it did not improve back-specific functional status, and the evidence does not support the use of TENS in the routine management of chronic LBP.
References
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Journal ArticleDOI

Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone.

TL;DR: The results suggest that satisfactory alleviation of persistent pain in humans may be obtained by electronic stimulation.
Journal ArticleDOI

Central nervous system mechanisms of analgesia.

TL;DR: The intent of this review is to examine and synthesize the extensive progress that has been made in the last few years describing the anatomical, physiological and neurohumoral substrates of neural systems which modulate pain perception.
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Naloxone blockade of acupuncture analgesia: endorphin implicated.

TL;DR: Electroacupuncture in awake mice produced analgesia to noxious heat stimuli causing a 54% increase in latency to squeak, implying that endorphin is released at a low basal rate in “normal” mice, and at a much higher rate during acupuncture.
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The influence of naloxone on analgesia produced by peripheral conditioning stimulation.

TL;DR: To see whether the analgesia experienced by the chronic pain patients is mediated via links utilizing endorphins, the opiate antagonist naloxone was administered to these patients under double-blind conditions, saline being used as a placebo, and it was found that 6 out of 10 patients receiving acupuncture-like stimulation but none out of10 patients receiving high frequency stimulation of skin nerves, reported an inhibition of the stimulation-produced analgesia by nAloxone.
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