Effective Parametric Image Sequencing Technology with Aggregate Space Profound Training

https://iopscience.iop.org/article/10.1088/1742-6596/1964/6/062070/pdf

We trained a large, deep convolutional neural network to classify the 1.2 million high-resolution images in the ImageNet LSVRC-2010 contest into the 1000 different classes. On the test data, we achieved top-1 and top-5 error rates of 37.5% and 17.0% which is considerably better than the previous state-of-the-art. The neural network, which has 60 million parameters and 650,000 neurons, consists of five convolutional layers, some of which are followed by max-pooling layers, and three fully-connected layers with a final 1000-way softmax. To make training faster, we used non-saturating neurons and a very efficient GPU implementation of the convolution operation. To reduce overriding in the fully-connected layers we employed a recently-developed regularization method called "dropout" that proved to be very effective. We also entered a variant of this model in the ILSVRC-2012 competition and achieved a winning top-5 test error rate of 15.3%, compared to 26.2% achieved by the second-best entry.

/pdf/imagenet-classification-with-deep-convolutional-neural-1190x9a6b9.pdf

ImageNet Classification with Deep Convolutional Neural Networks

Visual inspection of histopathology slides is one of the main methods used by pathologists to assess the stage, type and subtype of lung tumors. Adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) are the most prevalent subtypes of lung cancer, and their distinction requires visual inspection by an experienced pathologist. In this study, we trained a deep convolutional neural network (inception v3) on whole-slide images obtained from The Cancer Genome Atlas to accurately and automatically classify them into LUAD, LUSC or normal lung tissue. The performance of our method is comparable to that of pathologists, with an average area under the curve (AUC) of 0.97. Our model was validated on independent datasets of frozen tissues, formalin-fixed paraffin-embedded tissues and biopsies. Furthermore, we trained the network to predict the ten most commonly mutated genes in LUAD. We found that six of them—STK11, EGFR, FAT1, SETBP1, KRAS and TP53—can be predicted from pathology images, with AUCs from 0.733 to 0.856 as measured on a held-out population. These findings suggest that deep-learning models can assist pathologists in the detection of cancer subtype or gene mutations. Our approach can be applied to any cancer type, and the code is available at https://github.com/ncoudray/DeepPATH
 .

/pdf/classification-and-mutation-prediction-from-non-small-cell-9iqvajuj7y.pdf

Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning.

As a data-driven science, genomics largely utilizes machine learning to capture dependencies in data and derive novel biological hypotheses. However, the ability to extract new insights from the exponentially increasing volume of genomics data requires more expressive machine learning models. By effectively leveraging large data sets, deep learning has transformed fields such as computer vision and natural language processing. Now, it is becoming the method of choice for many genomics modelling tasks, including predicting the impact of genetic variation on gene regulatory mechanisms such as DNA accessibility and splicing. This Review describes different deep learning techniques and how they can be applied to extract biologically relevant information from large, complex genomic data sets.

Deep learning: new computational modelling techniques for genomics

We present an unsupervised representation learning approach using videos without semantic labels. We leverage the temporal coherence as a supervisory signal by formulating representation learning as a sequence sorting task. We take temporally shuffled frames (i.e., in non-chronological order) as inputs and train a convolutional neural network to sort the shuffled sequences. Similar to comparison-based sorting algorithms, we propose to extract features from all frame pairs and aggregate them to predict the correct order. As sorting shuffled image sequence requires an understanding of the statistical temporal structure of images, training with such a proxy task allows us to learn rich and generalizable visual representation. We validate the effectiveness of the learned representation using our method as pre-training on high-level recognition problems. The experimental results show that our method compares favorably against state-of-the-art methods on action recognition, image classification, and object detection tasks.

Unsupervised Representation Learning by Sorting Sequences

Automatic human affect recognition is a key step towards more natural human-computer interaction. Recent trends include recognition in the wild using a fusion of audiovisual and physiological sensors, a challenging setting for conventional machine learning algorithms. Since 2010, novel deep learning algorithms have been applied increasingly in this field. In this paper, we review the literature on human affect recognition between 2010 and 2017, with a special focus on approaches using deep neural networks. By classifying a total of 950 studies according to their usage of shallow or deep architectures, we are able to show a trend towards deep learning. Reviewing a subset of 233 studies that employ deep neural networks, we comprehensively quantify their applications in this field. We find that deep learning is used for learning of (i) spatial feature representations, (ii) temporal feature representations, and (iii) joint feature representations for multimodal sensor data. Exemplary state-of-the-art architectures illustrate the progress. Our findings show the role deep architectures will play in human affect recognition, and can serve as a reference point for researchers working on related applications.

Effective Parametric Image Sequencing Technology with Aggregate Space Profound Training

References

ImageNet Classification with Deep Convolutional Neural Networks

Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning.

Deep learning: new computational modelling techniques for genomics

Unsupervised Representation Learning by Sorting Sequences

Deep Learning for Human Affect Recognition: Insights and New Developments