Journal ArticleDOI
Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus
Marco Pezzati,Venturella Vangi,Roberto Biagiotti,Giovanna Bertini,Domenico Cianciulli,Firmino F. Rubaltelli +5 more
TLDR
Compared with indomethacin, ibuprofen did not significantly reduce mesenteric and renal blood flow velocity, and blood flow increased 120 minutes after treatment.About:
This article is published in The Journal of Pediatrics.The article was published on 1999-12-01. It has received 234 citations till now. The article focuses on the topics: Renal blood flow & Superior mesenteric artery.read more
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Journal ArticleDOI
A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus.
Bart Van Overmeire,Koen Smets,Dominiek Lecoutere,Hilde Van de Broek,Joost Weyler,Katya De Groote,Jean-Paul Langhendries +6 more
TL;DR: In a prospective study, ibuprofen and indomethacin are compared with regard to efficacy and safety for the early treatment of patent ductus arteriosus in preterm infants.
Journal ArticleDOI
Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?
TL;DR: Neither individual trials, pooled data from groups of randomized-controlled trials, nor critical examination of the immediate consequences of treatment provide evidence that medical or surgical closure of the ductus is beneficial in preterm infants, and these conclusions are supported by sufficient evidence.
Reference EntryDOI
Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants
TL;DR: The aim of this review was to determine the efficacy and safety of ibuprofen for closing a PDA in preterm and/or low birth weight infants and to reduce the risk of developing necrotising enterocolitis.
Journal ArticleDOI
Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants
Arne Ohlsson,Sachin S Shah +1 more
TL;DR: Prophylactic use of ibuprofen decreased the incidence of PDA, decreased the need for rescue treatment with cyclo-oxygenase inhibitors and decreased theneed for surgical closure, and until long-term follow-up results are published from the trials included in this updated review, no further trials of prophylaxis ibup rofen are recommended.
Journal ArticleDOI
Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all?
TL;DR: New information suggests that early pharmacologic treatment has several important short-term benefits for the preterm newborn, and ductus ligation, while eliminating the detrimental effects of a PDA on lung development, may create its own set of morbidities that counteract many of the benefits derived from ductus closure.
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Incidence and evolution of subependymal and intraventricular hemorrhage: A study of infants with birth weights less than 1,500 gm
TL;DR: There were no significant differences between the infants with and without IVH in birth weight, gestational age, one- and five-minute Apgar scores, or the need for resuscitation at birth or for subsequent respiratory assistance.
Journal ArticleDOI
Comparative evaluation of the effects of indomethacin and ibuprofen on cerebral perfusion and oxygenation in preterm infants with patent ductus arteriosus
TL;DR: Compared with indomethacin, treatment with ibuprofen does not significantly reduce cerebral perfusion and oxygen availability; the observed increase in cerebral blood volume requires further investigation.
Journal ArticleDOI
Gut blood flow velocities in the newborn: effects of patent ductus arteriosus and parenteral indomethacin.
TL;DR: The data suggest that there is a profound disturbance in mid gut perfusion in infants with patent ductus, which is exacerbated by indomethacin given rapidly by intravenous bolus, and may provide a rational explanation for the well recognised association between necrotising enterocolitis.
Journal ArticleDOI
Recommendations for the postnatal use of indomethacin: An analysis of four separate treatment strategies
Journal ArticleDOI
Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants.
Anastasia Varvarigou,Claudette Bardin,Kay D. Beharry,Sylvain Chemtob,Apostolos Papageorgiou,Jacob V. Aranda +5 more
TL;DR: Administration of three doses of ibuprofen within 3 hours after birth in preterm neonates reduced the incidence of PDA without causing notable early adverse drug reactions in this phase I trial.