Journal ArticleDOI
Effects of simulated increased gravity on the rate of aging of rats: implications for the rate of living theory of aging.
Angelos C. Economos,Jaime Miquel,Ralph C. Ballard,M. Blunden,K.A. Lindseth,J. Fleming,D.E. Philpott,J. Oyama +7 more
TLDR
Results show that a moderate increase of the level of basal metabolism of young adult rats adapted to hypergravity compared to controls in normal gravity is accompanied by a roughly similar increase in the rate of organ aging and reduction of survival, in agreement with Pearl's rate of living theory of aging, previously experimentally demonstrated only in poikilotherms.About:
This article is published in Archives of Gerontology and Geriatrics.The article was published on 1982-12-01. It has received 33 citations till now. The article focuses on the topics: Rate-of-living theory & Basal metabolic rate.read more
Citations
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Journal ArticleDOI
Role of oxidative stress in Drosophila aging.
TL;DR: Transgenic strains of Drosophila melanogaster are generated that synthesize excess levels of enzymatically active superoxide dismutase, a enzyme that catalyzes the dismutation of the superoxide radical to hydrogen peroxide and water, demonstrating that oxidative damage plays a role in governing the lifespan of Dosophila during normal metabolism and under conditions of environmental stress.
Book ChapterDOI
Gravitational and space biology at the cellular level
David Moore,Augusto Cogoli +1 more
TL;DR: Space biology can be said to have begun in the late 1940s, with the launch of monkey Albert on a U.S. rocket called ‘Blossom 3’ in 1948, before the first manned space flight took place in 1961.
Journal ArticleDOI
A return to time, cells, systems, and aging: III. Gompertzian models of biological aging and some possible roles for critical elements.
TL;DR: A mathematical model which has Gompertzian-like dynamics is derived which incorporates the deterministic failure of biological components with stochastic aspects of senescence and is used to obtain some of the lifespan curves found in the literature.
Journal ArticleDOI
Behavioural consequences of hypergravity in developing rats
TL;DR: The results show that hypergravity leads to a retarded development of motor aspects which are mainly dependent upon the vestibular system.
Journal ArticleDOI
Altered Behaviour in Hamsters Conceived and Born in Hypergravity
TL;DR: It is suggested that the persistent behavioural disturbances are caused by the embryonal development of the hamsters in a hypergravity environment and that hypergravity and rotation each have a different effect on behaviour.
References
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Book ChapterDOI
[7] Mitochondrial respiratory control and the polarographic measurement of ADP : O ratios
TL;DR: This chapter discusses the mitochondrial respiratory control and the polarographic measurement of ADP : O ratios and the principle of the oxygen electrode has been summarized, and the design of the vibrating oxygen electrode for use with speetrophotometric studies is illustrated.
Book ChapterDOI
[15] Isolation of liver or kidney mitochondria
Diane Johnson,Henry A. Lardy +1 more
TL;DR: This chapter describes the isolation of liver or kidney mitochondria and the method for testing the quality of mitochondria, with the exception that the mitochondrial pellet need be washed only once.
Journal ArticleDOI
Mitochondrial role in cell aging
TL;DR: The fine structural and biochemical data support the concept that the mitochondria of fixed postmitotic cells may be the site of intrinsic aging because of the attack by free radicals and lipid peroxides originating in the organelles as a by-product of oxygen reduction during respiration.
Related Papers (5)
A mild stress, hypergravity exposure, postpones behavioral aging in Drosophila melanogaster.
Éric Le Bourg,Nadège Minois +1 more