Effects of tetrodotoxin on innervated smooth muscle preparations.
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This article is published in British journal of pharmacology and chemotherapy.The article was published on 1967-03-01 and is currently open access. It has received 238 citations till now. The article focuses on the topics: Tetrodotoxin.read more
Citations
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Roles played by 5-hydroxytryptamine in the physiology of the bowel
TL;DR: In this article, the authors found that the major enteric depot of 5HT is found in mucosal enterochromaffin cells, which are sensory transducers that utilize 5HT to activate both intrinsic (via 5‐HT1P and 5−HT4 receptors) and extrinsic (via five-HT3 receptors) primary afferent nerves.
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Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel.
TL;DR: Antagonism of 5‐HT3 receptors by compounds such as alosetron should be useful in treating functional bowel disease because they can inhibit excitation of extrinsic sensory nerves by 5‐ HT without interfering with intrinsic enteric reflexes.
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Neurohumoral, hormonal, and drug receptors for the lower esophageal sphincter
Raj K. Goyal,Satish Rattan +1 more
TL;DR: Characterization of the receptors using selective agonists or antagonists has enhanced the understanding of the nature of the neurons and neurotransmitters involved in the regulation of LES function.
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5‐Hydroxytryptamine participation in the vagal inhibitory innervation of the stomach
TL;DR: Intraluminal pressure was recorded from the isolated guinea‐pig and mouse stomach with the vagus and sympathetic nerves attached and it was determined that the maximum pressure achievable with a single feeding is 3.1.
References
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Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant Axons
TL;DR: Observations have been made of sodium and potassium currents in the lobster giant axons treated with tetrodotoxin by means of the sucrose-gap voltage-clamp technique, and it is concluded that tetrodOToxin blocks the action potential production through its selective inhibition of the sodium-carrying mechanism while keeping the potassium- Carrying mechanism intact.
Journal Article
Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena
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Two kinds of tryptamine receptor
J. H. Gaddum,Z. P. Picarelli +1 more
TL;DR: There are two kinds of tryptamine receptor in the guinea-pig ileum, namely the M receptors which can be blocked with morphine and the D receptors which have no additional effect after dibenzyline.
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A sensitive method for the assay of 5‐hydroxytryptamine
TL;DR: The movements of a strip of fundus from a rat stomach, suspended in a 5 ml.
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