Journal ArticleDOI
ELISA in the Diagnosis of Neurocysticercosis
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TLDR
The use of the ELISA with serum is not reliable for diagnosis of NCC and therefore cannot be used routinely for the detection of cases or epidemiological studies; Conversely, ELISA used with CSF is highly dependable for detecting all forms of active NCC.Abstract:
• IgM antibodies against cysticercus antigens were measured by enzymelinked immunosorbent assay (ELISA) in 133 serum and 126 cerebrospinal fluid (CSF) samples from patients with active neurocysticercosis (NCC), in 61 serum and 32 CSF samples from patients with inactive NCC, and in 556 serum and 449 CSF samples from patients with other neurological disorders. For diagnosis of active NCC the test showed 50% sensitivity with 70% specificity in serum and 87% sensitivity with 95% specificity in CSF. We concluded that the use of the ELISA with serum is not reliable for diagnosis of NCC and therefore cannot be used routinely for the detection of cases or epidemiological studies. Conversely, ELISA used with CSF is highly dependable for detecting all forms of active NCC. The possible explanations for the discrepancy between serum and CSF results are discussed.read more
Citations
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Journal ArticleDOI
An Enzyme-Linked Immunoelectrotransfer Blot Assay and Glycoprotein Antigens for Diagnosing Human Cysticercosis (Taenia solium)
TL;DR: An enzyme-linked immunoelectrotransfer blot (EITB) assay was developed for immunodiagnosing human cysticercosis and identified seven major glycoprotein bands that are commonly recognized by virtually all serum and/or CSF samples from patients with confirmed cysticERCosis.
Journal ArticleDOI
Proposed diagnostic criteria for neurocysticercosis
O. H. Del Brutto,Vedantam Rajshekhar,A. C. White,Victor C. W. Tsang,Theodore E. Nash,Osvaldo Massaiti Takayanagui,P.M. Schantz,Carlton A. Evans,Ana Flisser,Dolores Correa,D. Botero,J. C. Allan,Elsa Sarti,Armando E. Gonzalez,Robert H. Gilman,Robert H. Gilman,Hector H. Garcia +16 more
TL;DR: Diagnosis of neurocysticercosis is provided based on objective clinical, imaging, immunologic, and epidemiologic data and Interpretation permits two degrees of diagnostic certainty.
Journal ArticleDOI
Taenia solium cysticercosis
Hector H. Garcia,Armando E. Gonzalez,Armando E. Gonzalez,Carlton A. Evans,Robert H. Gilman,Robert H. Gilman +5 more
TL;DR: Clinical manifestations vary because of the variable number, size, and location of the cysts and the immune response of the host.
Journal ArticleDOI
Taenia solium cysticercosis.
TL;DR: The larval stage of the pork tapeworm infects the human nervous system, causing neurocysticercosis, one of the main causes of epileptic seizures in many less developed countries and also increasingly seen in more developed countries because of immigration from endemic areas.
Journal ArticleDOI
Epilepsy due to neurocysticercosis Analysis of 203 patients
TL;DR: Clinical, EEG, and CT findings of 203 patients with epilepsy due to neurocysticercosis showed a strong correlation between the use of anticysticercal drugs and seizure control, and of the 21 patients in whom anticonvulsants were withdrawn, 16 had relapses.
References
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Journal ArticleDOI
Neurocysticercosis: A New Classification Based on Active and Inactive Forms: A Study of 753 Cases
TL;DR: A classification is presented that separates active from nonactive forms of NCC and is based on the experience with 735 patients studied, and characteristics of each form, frequency of principal signs and symptoms, and findings in cerebrospinal fluid analysis are discussed.
Journal ArticleDOI
Therapy of Parenchymal Brain Cysticercosis with Praziquantel
Julio Sotelo,Francisco Escobedo,Jesus Rodriguez-Carbajal,Bertha Torres,Francisco Rubio-Donnadieu +4 more
TL;DR: During treatment with the antihelmintic agent praziquantel a strong inflammatory reaction occurred, as evidenced by increased protein and cells in the cerebrospinal fluid, correlated with headache, exacerbation of neurologic symptoms, and edema and inflammation around cystic lesions.
Journal ArticleDOI
Praziquantel in the treatment of neurocysticercosis: Long‐term follow‐up
Julio Sotelo,Bertha Torres,Francisco Rubio-Donnadieu,Francisco Escobedo,Jesus Rodriguez-Carbajal +4 more
TL;DR: A single treatment with praziquantel for 2 weeks, administered in a daily dose of 50 mg/kg of body weight, was highly effective in parenchymal cysticercosis but less effective in meningeal cysticERCosis.
Journal Article
A simple method for detecting antibodies to rubella.
A. Voller,D. E. Bidwell +1 more
TL;DR: A simple microplate method of enzyme linked immunosorbent assay for Rubella antibody is described and this Micro-ELISA was compared with haemagglutination inhibition in a study of 188 human sera.