End-stage renal failure due to amyloidosis: outcomes in 490 ANZDATA registry cases
Wen Tang,Wen Tang,Stephen P. McDonald,Carmel M. Hawley,Sunil V. Badve,Neil Boudville,Fiona G. Brown,Philip A. Clayton,Scott B. Campbell,Janak de Zoysa,David W. Johnson +10 more
TLDR
Amyloidosis was associated with poor patient survival following dialysis and/or renal transplantation, poor renal allografted survival and a significant incidence of disease recurrence in the allograft.Abstract:
Wen Tang, Stephen P McDonald, Carmel M Hawley, Sunil V Badve, Neil Boudville, Fiona G Brown, Philip A Clayton, Scott B Campbell, Janak R de Zoysa and David W Johnsonread more
Citations
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Journal ArticleDOI
Cardiovascular Disease in Chronic Kidney Disease: Pathophysiological Insights and Therapeutic Options.
TL;DR: The authors explore the most important interactions between heart rhythm disorders and renal dysfunction while evaluating the ways in which the coexistence of renal dysfunction and cardiac arrhythmia influences the management of both.
Journal ArticleDOI
KDIGO Clinical Practice Guideline on the evaluation and management of candidates for kidney transplantation
Steven J. Chadban,Curie Ahn,David A. Axelrod,Bethany J. Foster,Bertram L. Kasiske,Vijah Kher,Deepali Kumar,Rainer Oberbauer,Julio Pascual,Helen Pilmore,James R. Rodrigue,Dorry L. Segev,Neil S. Sheerin,Kathryn Tinckam,Germaine Wong,Gregory A. Knoll +15 more
TL;DR: The goal is to assist the clinical team to assimilate all data relevant to an individual, consider this within their local health context, and make an overall judgment on candidacy for transplantation.
Journal ArticleDOI
Immunoglobulin light chain amyloidosis: 2014 update on diagnosis, prognosis, and treatment.
TL;DR: Clinical features depend on organs involved but can include heart failure with preserved ejection fraction, nephrotic syndrome, hepatic dysfunction, peripheral/autonomic neuropathy, and “atypical smoldering multiple myeloma or monoclonal gammopathy undetermined significance (MGUS).”
Journal ArticleDOI
Immunoglobulin light chain amyloidosis
TL;DR: Future efforts should be directed at early diagnosis, improving the tolerability and efficacy of anti-plasma cell therapy, accelerating recovery of organ function via promoting resorption of amyloid deposits, and developing novel approaches to counter light chain proteotoxicity.
Journal ArticleDOI
Immunoglobulin light chain amyloidosis: 2016 update on diagnosis, prognosis, and treatment: Ig Light Chain (AL) Amyloidosis
TL;DR: Clinical features depend on organs involved but can include restrictive cardiomyopathy, nephrotic syndrome, hepatic failure, peripheral/autonomic neuropathy, and atypical multiple myeloma.
References
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Journal ArticleDOI
Amyloidosis-Associated Kidney Disease
TL;DR: The kidney is one of the most frequent sites of amyloid deposition in AL, AA, and several of the hereditary amyloids, focusing heavily on the renal aspects of each of these areas.
Journal ArticleDOI
Outcome in Renal AL Amyloidosis After Chemotherapy
Jennifer H. Pinney,Helen J. Lachmann,Loveleen Bansi,Ashutosh D. Wechalekar,Janet A. Gilbertson,Dorota Rowczenio,Prayman T. Sattianayagam,Simon D. J. Gibbs,Emanuela Orlandi,Nancy Wassef,Arthur R. Bradwell,Philip N. Hawkins,Julian D. Gillmore +12 more
TL;DR: Renal outcome and overall outcome in AL amyloidsosis are strongly associated with FLC response to chemotherapy and are best among patients achieving more than 90% suppression of the amyloidogenic monoclonal component.
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Renal involvement in systemic amyloidosis* An Italian collaborative study on survival and renal outcome
Franco Bergesio,Anna Maria Ciciani,Marco Manganaro,Giovanni Palladini,M. Santostefano,R. Brugnano,A. M. Di Palma,Marco Gallo,Alberto Rosati,P. Tosi,Maurizio Salvadori +10 more
TL;DR: It is suggested that a late nephrological referral is likely the cause of the higher sCr found at presentation in patients with AA and probably accounts for the lower renal survival observed in the short term in these patients.
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Renal transplantation in 45 patients with amyloidosis.
TL;DR: The results of renal transplantation in patients with amyloidosis were studied in 45 patients receiving primary cadaver grafts at a single center between March 1973 and October 1981 and found that age over 40 years was the major factor determining low survival in these patients.
Journal ArticleDOI
Clinical outcome of immunoglobulin light chain amyloidosis affecting the kidney
Morie A. Gertz,Nelson Leung,Martha Q. Lacy,Angela Dispenzieri,Steven R. Zeldenrust,Suzanne R. Hayman,Francis K. Buadi,David Dingli,Philip R. Greipp,Shaji Kumar,John A. Lust,S. Vincent Rajkumar,Stephen J. Russell,Thomas E. Witzig +13 more
TL;DR: Presenting 24-h urine protein loss and creatinine values predict which patients will require dialysis, and the presence of lambda light chain amyloid predicts the increased likelihood of renal involvement.