Journal ArticleDOI
Endocarditis Due to Resistant Viridans Streptococci during Oral Penicillin Chemoprophylaxis
Joseph E. Parrillo,George C. Borst,Mark H. Mazur,Paul Lieutenant Commander Iannini,Mark S. Klempner,Robert C. Moellering,Seth E. Commander Anderson +6 more
Reads0
Chats0
TLDR
Follow-up studies of large numbers of patients taking prophylactic penicillin have found no increase in the incidence of endocarditis,10 and few cases of peniillin-resistant bacteria in the gingival flora.Abstract:
OPTIMAL management of patients with rheumatic heart disease or a previous bout of acute rheumatic fever includes the administration of prophylactic antibiotics to prevent pharyngeal infection with Group A streptococci.1 , 2 Several studies have shown that oral penicillin prophylaxis is associated with a high prevalence of penicillin-resistant bacteria in the gingival flora.3 4 5 6 7 8 9 An original concern was that continuous low-dose prophylaxis would result in a high incidence of endocarditis due to resistant organisms that would be difficult to cure. Follow-up studies of large numbers of patients taking prophylactic penicillin have found no increase in the incidence of endocarditis,10 and few cases of . . .read more
Citations
More filters
Journal ArticleDOI
Bacteremia Associated With Toothbrushing and Dental Extraction
Peter B. Lockhart,Michael T. Brennan,Howell C. Sasser,Philip C. Fox,Bruce J. Paster,Farah K. Bahrani-Mougeot +5 more
TL;DR: Although amoxicillin has a significant impact on bacteremia resulting from a single-tooth extraction, given the greater frequency for oral hygiene, toothbrushing may be a greater threat for individuals at risk for infective endocarditis.
Journal ArticleDOI
Prevention of infective endocarditis.
TL;DR: The Society of America, the International Society of Chemotherapy for Infection and Cancer, and this guideline has been endorsed by the American Academy of Pediatrics, Infectious Diseases, and the American Dental Association has approved the guideline as it relates to dentistry.
Journal ArticleDOI
Antibiotic tolerance among clinical isolates of bacteria.
TL;DR: This work has characterized a novel type of pneumococcal mutant that grows in normal generation times and is as sensitive to growth inhibition by penicillin as the wild-type parent strain.
Journal ArticleDOI
Transferable beta-lactamase. A new mechanism for in vitro penicillin resistance in Streptococcus faecalis.
B E Murray,B Mederski-Samaroj +1 more
TL;DR: Penicillin resistance and beta lactamase activity were transferred by conjugation at a high frequency to an enterococcal laboratory recipient strain together with two plasmids of molecular size 34 X 10(6) and 56 X10(6), thus demonstrating the emergence of plasmid-mediated penicillin Resistance in the genus Streptococcus.
Journal ArticleDOI
Antibiotic combinations: should they be tested?
TL;DR: The mechanisms of antibiotic interaction leading to synergism or antagonism are examined, attempts to correlate in vitro observations with efficacy in animal models are surveyed, and clinical data providing evidence for or against a useful role of synergistic antibiotic interactions in the treatment of human infections are reviewed.
References
More filters
Journal ArticleDOI
A Micro Precipitin-Technic for Classifying Hemolytic Streptococci, and Improved Methods for Producing Antisera:
TL;DR: Methods for producing high-titered group-specific antisera for classifying hemolytic streptococci into groups and a reliable micro-precipitin technic which can be used with very small amounts of bacterial extract and antiserum are described.
Journal ArticleDOI
Prevention of Rheumatic Fever
Floyd W. Denny,Elia M. Ayoub,Hugh C. Dillon,Frank A. Disney,Edward L. Kaplan,Max D. Moody,Philip Y. Paterson,Angelo Taranta +7 more
TL;DR: Bacterial endocarditis may result from dental and other surgical procedures in patients with rheumatic or congenital heart disease, and patients should be protected by administration of antibiotics in therapeutic doses.
Journal ArticleDOI
Synergy of Penicillin and Gentamicin against Enterococci
TL;DR: The combination of penicillin plus gentamicin produced enhanced killing of all enterococci tested when used in clinically achievable concentrations.
Journal ArticleDOI