Journal ArticleDOI
Enlarged synaptic vesicles as an early sign of secondary degeneration in the optic nerve terminals of the pigeon.
TLDR
The conclusion seems warranted that the ballooning of synaptic vesicles is an early sign of terminal degeneration, it appears to precede vesicular disintegration.Abstract:
The terminal degeneration of retino-tectal fibres was studied electron microscopically in the pigeon Synaptic vesicles seem to undergo systematic changes which can best be observed in aldehyde-fixed material. Initially (i.e. within 12-24 h) the vesicles begin to swell. The enlargement is clearly visible after 4 days (40 % increase in diameter) and reaches a maximum at 14 days (100% increase). At the latter stage, the enlargement is almost invariably associated with the well known opacity of degenerating terminals. In contrast, normal control tissue contains nerve endings with only a few enlarged and no ballooning vesicles. The conclusion seems warranted that the ballooning of synaptic vesicles is an early sign of terminal degeneration, it appears to precede vesicular disintegration.read more
Citations
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Journal ArticleDOI
Ultrastructural changes accompanying the disturbances of neuromuscular transmission caused by Pardachirus toxin.
TL;DR: Toxic secretion from the Red Sea flatfish Pardachirus marmoratus was applied to frog neuromuscular preparations while intracellular recording was done with microelectrodes, revealing lamellar and occasionally concentric arrangements of Schwann cells surrounding and intruding into nerve terminals.
Journal ArticleDOI
A quantitative electron microscope study of cerebellar axon terminals on the magnocellular red nucleus neurons in the cat
TL;DR: In the red nucleus of the cat, the bouton covering ratio and the density of axosomatic terminals in contact with somatic profiles and in the RN 11-63 days after the operation, both the BCR and DAST tended to re-increase slightly and the majority of the re- increased terminals appeared to be F-terminals.
Book ChapterDOI
Neurotransmitters in the Avian Visual System
M. Cuénod,H. Henke +1 more
TL;DR: Microiontophoretic application of the amino acid should mimic the effect of the physiological synaptic action of the transmitter on the postsynaptic element and specific antagonists should prevent this action.
Journal ArticleDOI
Myelin proteins, glycoproteins, and myelin-related enzymes in experimental demyelination of the rabbit optic nerve: sequence of events.
TL;DR: The results show that secondary myelin destruction in the absence of edema, hemorrhage, or macrophages is a very slow process, and in this situation myelin undergoes a selective and sequential loss of its constituents.
Journal ArticleDOI
Fine Structure of the Medial and Descending Vestibular Nuclei in Normal Rats and After Unilateral Transection of the Vestibular Nerve
TL;DR: Vestibular nerve transection resulted in degeneration of small SV terminals which were found from the first to fifth postoperative day in the ipsilateral nuclei, and Glycogen granules were found in various types of axon terminals bilaterally in the vestibular nuclei 3-5 days after right Vestibular transections.
References
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Journal ArticleDOI
Hemorrhages into peripheral nerves in association with leukemia.
Book ChapterDOI
Synaptic Morphology in the Normal and Degenerating Nervous System
E.G. Gray,R.W. Guillery +1 more
TL;DR: It is emphasized that, in addition to transmission of impulses, the organization of neuroneuronal junctions is likely to include other important properties that cannot be ignored when the morphology of synaptic contacts is being considered.
Journal Article
Electron microscopy of experimental degeneration in the avian optic tectum.
E. G. Gray,L. H. Hamlyn +1 more
TL;DR: In this paper, the authors used the simplified classification of the tectal layers used by Cragg, Evans & Hamlyn (1954) modified from van Gehuchten (1892) to study the effects of axons and their terminals.
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Electron microscopy of experimental degeneration in the avian optic tectum.
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