Journal ArticleDOI
Enlarged synaptic vesicles as an early sign of secondary degeneration in the optic nerve terminals of the pigeon.
TLDR
The conclusion seems warranted that the ballooning of synaptic vesicles is an early sign of terminal degeneration, it appears to precede vesicular disintegration.Abstract:
The terminal degeneration of retino-tectal fibres was studied electron microscopically in the pigeon Synaptic vesicles seem to undergo systematic changes which can best be observed in aldehyde-fixed material. Initially (i.e. within 12-24 h) the vesicles begin to swell. The enlargement is clearly visible after 4 days (40 % increase in diameter) and reaches a maximum at 14 days (100% increase). At the latter stage, the enlargement is almost invariably associated with the well known opacity of degenerating terminals. In contrast, normal control tissue contains nerve endings with only a few enlarged and no ballooning vesicles. The conclusion seems warranted that the ballooning of synaptic vesicles is an early sign of terminal degeneration, it appears to precede vesicular disintegration.read more
Citations
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Journal ArticleDOI
Observations on complex vesicles, neurofilamentous hyperplasia and increased electron density during terminal degeneration in the inferior colliculus
E. G. Jones,A. J. Rockel +1 more
TL;DR: The central nucleus of the inferior colliculus has been examined electron microscopically and findings confirm the differential distribution of lateral lemniscal and corticofugal fibers to the two divisions of the central nucleus and, in the case of the lateralLemniscal fibers, to theTwo cell types of the ventro‐lateral division.
Journal ArticleDOI
An evaluation of L-glutamate as the transmitter released from optic nerve terminals of the pigeon.
TL;DR: The possibility was investigated that L-glutamic acid is the excitatory transmitter released from the optic nerve terminals of the pigeon optic tectum and the results are discussed in relation to a possible role for L- glutamate as the 'optic nerve transmitter' and in the context of previous evidence implicating glutamate as an excitatories transmitter.
Journal ArticleDOI
A qualitative electron microscopic investigation of the anomalous corticofugal projections following neonatal lesions in the albino rats.
TL;DR: The present study confirms the suggestive evidence brought forth by the finding of Leong and Lund that following neonatal lesion of the sensorimotor and adjacent cortex of the albino rats, the remaining intact contralateral cortex projects bilaterally to the superior colliculus, pons and spinal cord.
Journal ArticleDOI
An electron microscopic study of the normal synaptic relationships and early degenerative changes in the rat olfactory tubercle.
TL;DR: The Olfactory tubercle of the rat was studied by electron microscopy both in the normal and after ipsilateral olfactory bulb ablation at survival times of from 14 hours to seven days, with particular emphasis on synaptic structures and their changes following the lesion.
Journal ArticleDOI
A study of terminal degeneration in the olfactory bulb of the rat.
A. J. Pinching,T. P. S. Powell +1 more
TL;DR: Observations on the persistence of post-synaptic thickenings in various sites in the central and peripheral nervous systems are reviewed and the problems arising out of the morphological identification of apposition or reinnervations are discussed.
References
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Journal ArticleDOI
Hemorrhages into peripheral nerves in association with leukemia.
Book ChapterDOI
Synaptic Morphology in the Normal and Degenerating Nervous System
E.G. Gray,R.W. Guillery +1 more
TL;DR: It is emphasized that, in addition to transmission of impulses, the organization of neuroneuronal junctions is likely to include other important properties that cannot be ignored when the morphology of synaptic contacts is being considered.
Journal Article
Electron microscopy of experimental degeneration in the avian optic tectum.
E. G. Gray,L. H. Hamlyn +1 more
TL;DR: In this paper, the authors used the simplified classification of the tectal layers used by Cragg, Evans & Hamlyn (1954) modified from van Gehuchten (1892) to study the effects of axons and their terminals.
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