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Journal ArticleDOI

Enthalpy–entropy compensation for the solubility of drugs in solvent mixtures: Paracetamol, acetanilide, and nalidixic acid in dioxane–water

Pilar Bustamante, +4 more
- 01 Dec 1998 - 
- Vol. 87, Iss: 12, pp 1590-1596
TLDR
The behavior of the apparent thermodynamic magnitudes for the solubility of paracetamol, acetanilide, and nalidixic acid is studied and suggests that the nonlinear enthalpy-entropy compensation effect may be characteristic of the solubsility of semipolar drugs in dioxane-water mixtures.
About: 
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1998-12-01. It has received 235 citations till now. The article focuses on the topics: Solubility & Enthalpy–entropy compensation.

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Citations
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Journal ArticleDOI

Isokinetic relationship, isoequilibrium relationship, and enthalpy-entropy compensation.

Lei Liu, +1 more
- 02 Feb 2001 - 
Journal ArticleDOI

Solubility and preferential solvation of indomethacin in 1,4-dioxane+water solvent mixtures

Miller A. Ruidiaz, +3 more
- 25 Dec 2010 - 
TL;DR: In this paper, the solubility of indomethacin (IMC) in 1,4-dioxane+water cosolvent mixtures was determined at several temperatures, 293.15-313.15 K. The authors used van't Hoff and Gibbs equations to obtain the thermodynamic functions: Gibbs energy, enthalpy, and entropy of solution and of mixing.
Journal ArticleDOI

On the preferential solvation of drugs and PAHs in binary solvent mixtures

Yizhak Marcus
- 15 Apr 2008 - 
TL;DR: In this paper, the preferential solvation parameters, i.e., the differences between the local and bulk mole fractions of the solvents in solutions of certain drugs and polycyclic aromatic hydrocarbons (PAHs), are derived from their solubilities in binary solvent mixtures by means of the inverse Kirkwood-Buff integral (IKBI) and the quasi-lattice quasi-chemical (QLQC) methods.
Journal ArticleDOI

Solubility of Carvedilol in Ethanol + Propylene Glycol Mixtures at Various Temperatures

Sahel Vahdati, +6 more
- 30 Oct 2013 - 
TL;DR: In this paper, the solubility of carvedilol in ethanol and propylene glycol mixtures at various temperatures was investigated and the results showed that carvedilols are solubile in both types of mixtures.
Journal ArticleDOI

Phase Transition Enthalpy Measurements of Organic and Organometallic Compounds. Sublimation, Vaporization and Fusion Enthalpies From 1880 to 2015. Part 1. C1-C10

William E. Acree, +1 more
- 21 Jul 2016 - 
TL;DR: A compendium of phase change enthalpies including fusion, vaporization, and sublimation was published in 2010 as mentioned in this paper, which included organic, organometallic, and a few inorganic compounds.
References
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Journal ArticleDOI

Enthalpy-entropy compensation. 2. Separation of the chemical from the statistical effect

R. R. Krug, +2 more
- 01 Oct 1976 - 
Journal ArticleDOI

Non – linear van't hoff solubility temperature plots and their pharmaceutical interpretation

David J.W. Grant, +3 more
- 01 Jan 1984 - 
TL;DR: In this paper, the aqueous solubilities of acetaminophen, adipic acid and the parabens (methyl, ethyl, propyl and butyl p -hydroxybenzoate) have been measured over a temperature span of at least 50°C.
Journal ArticleDOI

Hydrogen-bonded complex formation. III. Thermodynamics of complexing by infrared spectroscopy and calorimetry

Edward M. Arnett, +5 more
- 01 Apr 1970 - 
Journal ArticleDOI

The Monoclinic Form of p-Hydroxyacetanilide

M. Haisa, +3 more
- 15 Apr 1976 - 
Journal ArticleDOI

Strength of molecular complexation of apolar solutes in water and in organic solvents is predictable by linear free energy relationships: a general model for solvation effects on apolar binding

David B. Smithrud, +1 more
- 01 Jan 1990 - 
TL;DR: La stabilite d'un complexe d'inclusion forme par un cyclophane macrobicyclique, compose hote et le pyrene est etudiee dans l'eau et dans differents solvants organiques, de different polarites as discussed by the authors.