Showing papers in "International Journal of Pharmaceutics in 1984"

TL;DR: To examine a large number of polymers as to their bioadhesive potential and to derive meaningful information on the structural requirements for bioadhesion a new, simple experimental technique that can quantitatively measure bioad adhesive properties of various polymers has been developed.

TL;DR: In this paper, the aqueous solubilities of acetaminophen, adipic acid and the parabens (methyl, ethyl, propyl and butyl p -hydroxybenzoate) have been measured over a temperature span of at least 50°C.

TL;DR: In this article, a linear relationship was found between the logarithm of the pluronic polyol concentration and the reciprocal of the gel-sol transition temperature for all polymers having the same ratio of poly(oxypropylene) to poly (oxyethylene) units per mole of polymer, (P/E ratio).

TL;DR: The transits of the formulations were found to be highly dependent on food intake and there was a good correlation between transit times (gastric emptying, arrival at colon) and the calorific value of the meal taken shortly before dosing.

TL;DR: The steady-state diffusion of phenol, methanol, octanol and caffeine, and the finite dose diffusion of aspirin and caffeine were measured and a vasoconstrictor assay with betamethasone-17-benzoate in 9 vehicles was performed.

TL;DR: A review of the literature revealed several inconsistencies and uncertainties in values obtained for the specific surface area of microcrystalline cellulose, as well as the proposed mechanisms of water vapor sorption.

TL;DR: The transit from the stomach through the small intestine to the colon was influenced by the nature of the meal taken shortly before dosing, and the concept of the ‘reserve length’ for drug absorption was discussed.

TL;DR: Results of permeation experiments involving finite dose diffusion cells with hairless mouse skin as the membrane indicate that neither intact liposomes nor the phospholipid of which they are comprised diffuses across the skin.

TL;DR: In this paper, the rheological behavior of poloxamer vehicles as a function of composition and temperature was evaluated using continuous shear methods, and a linear relationship was observed between shear rate and shear stress.

TL;DR: In this paper, the effect of collagen structure, crosslinking density, hydrophilicity of crosslinker, and membrane porosity on macromolecular diffusion was studied.

TL;DR: In this paper, the effect of various variables on the size of albumin microspheres was evaluated and an optimal method for microsphere preparation was presented, and the particle size analysis was performed by electron microscopy.

TL;DR: In this paper, five viscous polymeric vehicles containing 0.2% tropicamide were tested for mydriatic activity in humans and in rabbits, and the hypothesis is advanced that some polymers may increase the ocular bioavailability of tropicaamide not by viscous effects aione, but also by influencing the spreading characteristics and the thickness of the medication layer over the precorneal area.

TL;DR: In this paper, a melt granulation process for the manufacture of divided unit, sustained release dosage forms is described, and results demonstrate that the product is not adversely affected by minor changes in the processing conditions.

TL;DR: According to as mentioned in this paper, carbamazepine dihydrate crystals grow by the whisker mechanism (or mechanisms) and the habit, the dimensions of the crystals and their rapid growth indicate this.

TL;DR: It is shown that the nasal route for the administration of naloxone and buprenorphine can be considered as effective as the parenteral route.

TL;DR: In this paper, the authors studied the shelf life of doxorubicin (DXR) containing negatively charged liposomes under various conditions, and compared the performance of a bilayer interacting compound and a non-interacting compound.

TL;DR: In this paper, an automated diffusion apparatus was developed, holding 24 stainless steel diffusion cells with flow-through receptor solution, which can be used for pseudo-steady-state or in vivo mimic procedures, and requires only small samples of skin.

TL;DR: In this article, the authors present a review of the literature on purity determinations with differential scanning calcorimetry (DSC), focusing on the van't Hoff's law of melting point depression.

TL;DR: In this article, a method for the measurement of the rate of transit of a non-disintegrating object through the gastrointestinal tract of human subjects using a gamma camera was described.

TL;DR: Mild loading conditions have given excellent results in experiments involving the depletion of endogenous substrates by encapsulated enzymes and in where experiments where the circulating cells have acted as a slow release system for drugs.

TL;DR: Isotopic effects of deuterated aromatic compounds are demonstrated in the lipophilicity, measured by shake-flask and HPLC methods, of a series of compounds as discussed by the authors.

TL;DR: In this paper, the kinetics and mechanism of decomposition of nine N 1 -acyl derivatives of 5-fluorouracil in aqueous solution and in human plasma at 37°C were studied.

TL;DR: In this article, the dissolution rate and enthalpy of solution (ΔHs) of harvested adipic acid were investigated in the presence of various concentrations of hexanoic, octanoic and undecanoic acid.

TL;DR: Due to its facile enzymatic conversion in plasma or blood, excellent solubility properties, and case of synthesis and purification, the hydrochloride of metronidazole N,N-dimethylglycinate appears to be the most promising prodrug candidate as a patenterai delivery form of metronsidazoles.

TL;DR: In this paper, the torsional braid pendulum was used to measure the glass transition temperature of formulations using the Torsional Braz pendulum, a dynamic mechanical technique originally invented for following the rigidity changes accompanying the curing of polymers.

TL;DR: Evidence is presented that the intestinal mucus gel layer may be described by a macromolecular network model, where the chains are held together by permanent entanglements of a physical and chemical nature.