Enzyme inactivation with shearing
Stanley E. Charm,Bing L. Wong +1 more
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This article is published in Biotechnology and Bioengineering.The article was published on 1970-11-01 and is currently open access. It has received 151 citations till now.read more
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Journal ArticleDOI
Instability, stabilization, and formulation of liquid protein pharmaceuticals.
TL;DR: The basic behavior of proteins, their instabilities, and stabilization in aqueous state in relation to the development of liquid protein pharmaceuticals is discussed.
Journal ArticleDOI
Strategic approaches for overcoming peptide and protein instability within biodegradable nano- and microparticles
TL;DR: The various means usually employed for overcoming obstacles that are closely involved in peptide and protein degradation during the preparation of biodegradable nano- and microparticles are described.
Journal ArticleDOI
The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone
TL;DR: Stability of the solid was optimal when produced from solutions in the pH range, 7–7.5, with severe aggregation being observed at high pH, and the observation that dextran 40 formulations showed poor stability toward aggregation demonstrates that an amorphous excipient system is not a sufficient condition for stability.
Patent
Solid dose delivery vehicle and methods of making same
TL;DR: In this paper, a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis.
Journal ArticleDOI
Kinetic dynamics in heterogeneous enzymatic hydrolysis of cellulose: an overview, an experimental study and mathematical modelling
TL;DR: In this article, the authors present an experimental study and mathematical analysis of how reaction kinetics of enzymatic cellulose hydrolysis are influenced by the changing dynamics and nature of interactions between enzymes, cellulose substrate, products (reducing sugars), and non-hydrolytic materials in a heterogeneous solid-liquid reaction system.