Journal ArticleDOI
Estrogenic Antagonism of Metabolic Effects of Administered Growth Hormone
TLDR
In 3 mildly osteoporotic male patients, human growth hormone administration produced increased urinary calcium and hydroxyproline excretion without reduction of fecal calcium, effects considered compatible with increased bone resorption.Abstract:
In 3 mildly osteoporotic male patients, human growth hormone administration produced increased urinary calcium and hydroxyproline excretion without reduction of fecal calcium, effects considered compatible with increased bone resorption. During growth hormone therapy, the serum phosphorus rose without definite reduction of urinary phosphorus excretion, suggesting a possible nonrenal origin of the hyperphosphatemic action of growth hormone. The expected anabolic effects of growth hormone were also observed, including reduction of blood urea nitrogen and of urinary nitrogen excretion. Superimposed estrogen therapy reduced the elevations of urinary calcium, urinary hydroxyproline, and of serum phosphorus, and antagonized the nitrogen-retaining effects of growth hormone. While there was no significant reduction in urinary phosphorus excretion during growth hormone therapy, concomitant estrogen administration appeared to produce detectable phosphaturia in 2 patients. The favorable effect of estrogen u...read more
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Journal ArticleDOI
Sexual dimorphism in the control of growth hormone secretion.
TL;DR: A feminization of the liver develops after continuous, but not intermittent, administration of GH to hypophysectomized rats, suggesting that high, infrequent GH pulses with low plasma GH levels in between promotes growth more effectively than an intermediate, rather constant level of plasma GH.
Journal ArticleDOI
Long-term effects of ovariectomy and aging on the rat skeleton
TL;DR: The data indicate that a slow rate of bone loss and increased bone turnover persist in OVX rats during the later stages of estrogen deficiency, and the development of osteopenia is coincident with increasedBone turnover in OvX rats as well as in aged, control rats.
Journal ArticleDOI
Skeletal alterations in ovariectomized rats
TL;DR: In this paper, a twofold decrease in trabecular bone volume was noted in the proximal tibial metaphysis of ovariectomized rats and this bone loss was associated with elevated histomorphometric indices of bone resorption and formation.
Journal ArticleDOI
Gonadal hormones and behavioral regulation of body weight
TL;DR: Gonadal hormones have important effects on the behaviors that determine body weight in laboratory rats, and may act directly on separate neural loci to inhibit food intake and stimulate locomotor activity, possibly by lowering the set-point of a hypothalamic lipostat.
Book ChapterDOI
Sex Hormones, Regulatory Behaviors, and Body Weight
TL;DR: An ideal weight-control drug would be one that acts on neural weight-regulating systems to lower body weight set-point without being estrogenic or anti-estrogenic in other hormone-sensitive systems.