Journal ArticleDOI
Evolutionary significance of the HL-A system.
TLDR
It is still an open question how the genetic polymorphism represented by the principal human histocompatibility system is maintained, but it may have evolved as a consequence of the necessity for cell to cell recognition during development and morphogenesis.Abstract:
It is still an open question how the genetic polymorphism represented by the principal human histocompatibility system is maintained. But it may have evolved as a consequence of the necessity for cell to cell recognition during development and morphogenesis.read more
Citations
More filters
Journal ArticleDOI
Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection
Austin L. Hughes,Masatoshi Nei +1 more
TL;DR: Examination of the pattern of nucleotide substitution between polymorphic alleles in the region of the antigen recognition site (ARS) indicates that in ARS the rate of nonsynonymous substitution is significantly higher than that of synonymous substitution in both humans and mice, whereas in other regions the reverse is true.
Book ChapterDOI
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
TL;DR: This chapter focuses on the important discovery that virus-specific cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by the major histocompatibility complex (MHC).
Journal ArticleDOI
Common West African HLA antigens are associated with protection from severe malaria
Adrian V. S. Hill,Catherine E. M. Allsopp,Dominic P. Kwiatkowski,Nicholas M. Anstey,Patrick Twumasi,P. Rowe,Stephen Bennett,David Brewster,Andrew J. McMichael,Brian M. Greenwood +9 more
TL;DR: Data support the hypothesis that the extraordinary polymorphism of major histocompatibility complex genes has evolved primarily through natural selection by infectious pathogens.
Journal ArticleDOI
Complete sequence and gene map of a human major histocompatibility complex
Stephan Beck,Daniel E. Geraghty,Hidetoshi Inoko,Lee Rowen,B Aguado,Seiamak Bahram,RD Campbell,Simon Forbes,Thierry Guillaudeux,Leroy Hood,Roger Horton,Marta Janer,Christine L. Jasoni,A Madan,Sarah Milne,M Neville,Akira Oka,S Qin,G Ribas-Despuig,Jane Rogers,Takashi Shiina,Thomas Spies,Gen Tamiya,Hiroyuki Tashiro,John Trowsdale,Quyen Vu,L Williams,M Yamazaki +27 more
TL;DR: The first complete sequence and gene map of a human major histocompatibility complex (MHC), a region on chromosome 6 which is essential to the immune system, is reported, expected to be invaluable for the identification of many common disease loci.
References
More filters
Journal ArticleDOI
A molecular approach to the study of genic heterozygosity in natural populations. ii. amount of variation and degree of heterozygosity in natural populations of drosophila pseudoobscura
Richard C Lewontin,J. L. Hubby +1 more
TL;DR: This study shows that there is a considerable amount of genic variation segregating in all of the populations studied and that the real variation in these populations must be greater than the authors are able to demonstrate.
Related Papers (5)
Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection
Austin L. Hughes,Masatoshi Nei +1 more