Open AccessJournal Article
Experimental methods for evaluation of psychotropic agents in rodents: I--Anti-anxiety agents.
Salil K. Bhattacharya,K S Satyan +1 more
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TLDR
Rodent models of clinical anxiety are extensively used for evaluating putative anxiolytic activity and the available methods which can be utilized by most laboratories, have been discussed.Abstract:
Rodent models of clinical anxiety are extensively used for evaluating putative anxiolytic activity. In the present review, the available methods which can be utilized by most laboratories, have been discussed. These methods have been categorized as methods involving conditioning techniques and those not involving conditioning. In most cases, the methodology has been briefly discussed in terms of experimental use and efficacy of benzodiazepine and the newer non-benzodiazepine anxiolytics.read more
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Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study.
TL;DR: Investigation of the anxiolytic and antidepressant actions of the bioactive glycowithanolides of Withania somnifera, isolated from WS roots, in rats support the use of WS as a mood stabilizer in clinical conditions of anxiety and depression in Ayurveda.
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Reversal of Oxidative Stress-Induced Anxiety by Inhibition of Phosphodiesterase-2 in Mice
TL;DR: It is indicated that oxidative stress induces anxiety-like behavior in mice and that PDE2 inhibition reverses it through an increase in cGMP signaling, suggesting a novel pharmacological target for treatment of anxiety in neuropsychiatric and neurodegenerative disorders that involve oxidative stress.
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Pharmacologic overview of Withania somnifera, the Indian Ginseng
TL;DR: Withania somnifera is a potential drug candidate to treat various clinical conditions, particularly related to the nervous system, and the mechanisms of action and potential therapeutic applications of the plant and its active constituents are discussed.
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Effect of Morus alba L. (mulberry) leaves on anxiety in mice
TL;DR: The results of the present study suggest that a methanolic extract of M. alba leaves may possess an anxiolytic effect.
Journal ArticleDOI
Anxiolytic activity of a standardized extract of Bacopa monniera: an experimental study.
Salil K. Bhattacharya,S. Ghosal +1 more
TL;DR: B. monniera produced a dose-related anxiolytic activity, qualitatively comparable to that of lorazepam, in all the test parameters, however, statistically significant results were elicited usually by the higher two doses of BM, which correlate with the clinical use of the plant in Ayurveda.