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Open AccessJournal ArticleDOI

Extraskeletal myxoid chondrosarcoma in the lung: asymptomatic lung mass with severe anemia

TLDR
A 51-year-old Asian female initially manifested with signs of severe anemia who presented with a lung mass unrelated to pleura that was morphologically typical EMC, with strong immunoreactivity for vimentin and NSE after resection, and the anemia was cured.
Abstract
Extraskeletal myxoid chondrosarcoma (EMC) is a rare soft-tissue sarcoma, which primarily occurs deep in the extremities, especially in skeletal muscle, or tendon. EMC of the pleura has been described, however, no case of primary EMC arising from lung has been previously reported. We describe herein, a 51-year-old Asian female initially manifested with signs of severe anemia who presented with a lung mass unrelated to pleura that was morphologically typical EMC, with strong immunoreactivity for vimentin and NSE. Two weeks after resection, the anemia was cured. The patient continued with follow-up, without sign of abnormality 32 months after operation. The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2882199847396682

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Intravenous Iron Administration and Hypophosphatemia in Clinical Practice

TL;DR: Hypophosphatemia is frequent after parenteral FCM injection and may have clinical consequences, including persistent fatigue, but no immediate clinical consequence was found except for persistent fatigue despite anemia correction in some patients.
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Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion, resembling extraskeletal myxoid chondrosarcoma: Case report with a review of Literature

TL;DR: Findings indicate that the current tumor is an additional case of PPMS with EESR1‐CREB1 fusion, recently reported by Thway et al, and could not demonstrate EWSR1‐ATF1 fusion orEWSR1/TAF15/TFG‐NR4A3 fusion.
Journal ArticleDOI

Primary pulmonary myxoid sarcomas with EWSR1-CREB1 translocation might originate from primitive peribronchial mesenchymal cells undergoing (myo)fibroblastic differentiation

TL;DR: It is concluded that primary pulmonary myxoid sarcoma is an intermediate grade malignant lung tumor harboring EWSR1 translocations, which may originate from mesenchymal cells that undergo fibroblastic or myofibroBlastic differentiation.
Journal ArticleDOI

Sclerosing rhabdomyosarcoma presenting in the masseter muscle: a case report

TL;DR: Focused on the morphological finding and immunostaining, a case of SRMS occurring in the masseter muscle in a 40-year-old male displayed a cribriform pattern resembling adenoid cystic carcinoma, which may represent a new histological feature which can broaden the histological spectrum of this tumor.
Journal ArticleDOI

Primary Pulmonary Myxoid Sarcoma and Myxoid Angiomatoid Fibrous Histiocytoma: A Unifying Continuum With Shared and Distinct Features.

TL;DR: Findings provide new evidence supporting the concept that PPMS and a myxoid variant of AFH represent a continuum with overlapping histologic, immunohistochemical, and genetic features.
References
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Journal ArticleDOI

Extraskeletal myxoid chondrosarcoma: An analysis of 34 cases

TL;DR: It is remarkable that all three living patients with metastasis were still alive 10, 12, and 20 years after the initial surgery, and it is of particular importance because of the difference in behavior.
Journal ArticleDOI

Skeletal and extraskeletal myxoid chondrosarcoma: A comparative clinicopathologic, ultrastructural, and molecular study

TL;DR: This study represents the first systematic attempt to answer the question: are SMC and EMC the same entity arising in two different locations, or are they two separate entities?
Journal ArticleDOI

Anemia in cancer.

TL;DR: In terms of therapy, iron is used more and more; the late side effects of transfusions are not really understood and the recent controversy regarding erythropoietin usage has resulted in regulatory authorities and scientific societies providing several recommendations and guidelines.
Journal ArticleDOI

Extraskeletal myxoid chondrosarcoma: a Multi-Institutional Study of 42 Cases in Japan.

TL;DR: Extraskeletal myxoid chondrosarcoma is a rare malignant neoplasm and despite a consensus for the distinct clinicopathologic entity of EMC, its clinical features remain controversial.
Journal ArticleDOI

Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno-ultrastructural study indicating neuroendocrine differentiation

TL;DR: Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno‐ultrastructural study indicating neuroendocrine differentiation indicates neuro endocrine differentiation.
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