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Book ChapterDOI

Eyelid and Periocular Skin Tumors

TLDR
Orbital invasion from eyelid tumors usually results from a delayed presentation/diagnosis, incomplete treatment with subsequent recurrences, and highly aggressive invasive tumors.
Abstract
Malignant skin neoplasias commonly affect the eyelids and periocular region, particularly in high UV exposure zones. Secondary orbital invasion is a serious and potentially fatal complication of cutaneous tumors. The most frequent skin tumors resulting in orbital invasion are basal cell carcinoma, squamous cell carcinoma, sebaceous gland carcinoma, and malignant melanomas. Orbital invasion from eyelid tumors usually results from a delayed presentation/diagnosis, incomplete treatment with subsequent recurrences, and highly aggressive invasive tumors.

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Journal Article

Orbital exenteration with spontaneous granulation

TL;DR: In this article, spontaneous granulation tissue has been used to allow the orbit to heal spontaneously with granulation tissues, which has several advantages over the popular technique of lining the orbital walls with a split-thickness skin graft.
Journal ArticleDOI

Review of Targeted Therapies for Periocular Tumors.

TL;DR: Common eyelid and periocular malignancies are discussed, as well as novel-targeted therapies to treat these cancers.
References
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Journal ArticleDOI

Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.

TL;DR: The depth of invasion was studied using the criteria for staging of Clark et al.2 to see if maximal cross-sectional area, thickness, stage of invasion, or a combination of these can be of value in assessing the prognosis of cutaneous melanoma.
Journal Article

The Histogenesis and Biologic Behavior of Primary Human Malignant Melanomas of the Skin

TL;DR: Evidence is presented suggesting that superficial spreading melanoma and lentigo maligna melanoma (Hutchinson9s melanotic freckle) show a long period of superficial growth, followed by the relatively rapid appearance of nodules or deeper invasion within the primary lesion.
Journal ArticleDOI

Management of cutaneous melanoma.

TL;DR: The authors of this review discuss the pathogenesis and management of cutaneous melanoma and provide perspective on treatment options.
Journal ArticleDOI

Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome.

TL;DR: Vismodegib reduces the basal-cell carcinoma tumor burden and blocks growth of new basal- cell carcinomas in patients with the basal -cell nevus syndrome and the adverse events associated with treatment led to discontinuation in over half of treated patients.
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