Journal ArticleDOI
Fast and Noninvasive Characterization of Suspicious Lesions Detected at Breast Cancer X-Ray Screening: Capability of Diffusion-weighted MR Imaging with MIPs.
Sebastian Bickelhaupt,Frederik Bernd Laun,Jana Tesdorff,Wolfgang Lederer,Heidi Daniel,Anne Stieber,Stefan Delorme,Heinz Peter Schlemmer +7 more
TLDR
Unenhanced diagnostic MR imaging (DWIBS mammography), with an NPV of 0.92 and an acquisition time of less than 7 minutes, could help exclude malignancy in women with suspicious x-ray screening mammograms and has the potential to reduce unnecessary invasive procedures and emotional distress for breast cancer screening participants.Abstract:
Diagnostic MR imaging (diffusion-weighted imaging with background suppression) can reveal false-positive x-ray screening mammography findings before biopsy, yielding a negative predictive value of 0.92 (95% confidence interval: 0.75, 0.99) and, if used as a complement after x-ray mammography, could help reduce unnecessary invasive procedures and emotional distress for breast cancer screening participants.read more
Citations
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Journal ArticleDOI
Diffusion-weighted breast MRI: Clinical applications and emerging techniques
Savannah C. Partridge,Savannah C. Partridge,Noam Nissan,Habib Rahbar,Habib Rahbar,Averi E. Kitsch,Averi E. Kitsch,Eric E. Sigmund +7 more
TL;DR: Technical innovations are helping to overcome many of the image quality issues that have limited widespread use of DWI for breast imaging and advanced modeling approaches to further characterize tissue perfusion, complexity, and glandular organization may expand knowledge and yield improved diagnostic tools.
Journal ArticleDOI
Contrast-enhanced MRI for breast cancer screening.
TL;DR: MRI preferentially detects the more aggressive/invasive types of breast cancer, but has a higher sensitivity than mammography for any type of cancer, which implies that in women screened with breast MRI, all other examinations must be regarded as supplemental.
Journal ArticleDOI
Diffusion-Weighted Imaging With Apparent Diffusion Coefficient Mapping for Breast Cancer Detection as a Stand-Alone Parameter Comparison With Dynamic Contrast-Enhanced and Multiparametric Magnetic Resonance Imaging
Katja Pinker,Linda Moy,Elizabeth J. Sutton,Ritse M. Mann,Michael Weber,Sunitha B. Thakur,Maxine S. Jochelson,Zsuzsanna Bago-Horvath,Elizabeth A. Morris,Pascal Baltzer,Thomas H. Helbich +10 more
TL;DR: Dynamic contrast-enhanced MRI is most sensitive for breast cancer detection and thus still indispensable, and multiparametric MRI using DCE-MRI and DWI maintains a high sensitivity, increases specificity, and maximizes diagnostic accuracy, often preventing unnecessary breast biopsies.
Journal ArticleDOI
Prediction of malignancy by a radiomic signature from contrast agent-free diffusion MRI in suspicious breast lesions found on screening mammography.
Sebastian Bickelhaupt,Daniel Paech,Philipp Kickingereder,Philipp Kickingereder,Franziska Steudle,Wolfgang Lederer,Heidi Daniel,Michael Götz,Nils Gählert,Diana Tichy,Manuel Wiesenfarth,Frederik Bernd Laun,Klaus H. Maier-Hein,Heinz Peter Schlemmer,David Bonekamp +14 more
TL;DR: To assess radiomics as a tool to determine how well lesions found suspicious on breast cancer screening X‐ray mammography can be categorized into malignant and benign with unenhanced magnetic resonance (MR) mammography with diffusion‐weighted imaging and T2‐weighting sequences is assessed.
Journal ArticleDOI
Abbreviated MRI of the Breast: Does It Provide Value?
Doris Leithner,Linda Moy,Elizabeth A. Morris,Maria Adele Marino,Maria Adele Marino,Thomas H. Helbich,Katja Pinker +6 more
TL;DR: Results with abbreviated MRI protocols suggest that it seems feasible to offer screening breast DCE‐MRI to a broader population, and their emerging role in the new value‐based healthcare paradigm that has replaced the fee‐for‐service model is given.
References
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Journal Article
Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display.
TL;DR: In this article, the authors examined a new way of body diffusion weighted imaging (DWI) using the short TI inversion recovery-echo planar imaging (STIR-EPI) sequence and free breathing scanning (diffusion weighted whole body imaging with background body signal suppression; DWIBS) to obtain three-dimensional displays.
Book ChapterDOI
Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS)
Taro Takahara,Thomas C. Kwee +1 more
TL;DR: Three-dimensional DWIBS can be obtained with this technique, which may allow us to screen for malignancies in the whole body through diffusion weighted whole body imaging with background body signal suppression.
Journal ArticleDOI
Swedish two-county trial: impact of mammographic screening on breast cancer mortality during 3 decades.
Laszlo Tabar,Bedrich Vitak,Tony Hsiu Hsi Chen,Amy Ming Fang Yen,Anders Cohen,Tibor Tot,Sherry Yueh Hsia Chiu,Sam Li Sheng Chen,Jean Ching Yuan Fann,Johan Rosell,Helena Fohlin,Robert A. Smith,Stephen W. Duffy +12 more
TL;DR: Invitation to mammographic screening results in a highly significant decrease in breast cancer-specific mortality, and Evaluation of the full impact of screening, in particular estimates of absolute benefit and number needed to screen, requires follow-up times exceeding 20 years.
Journal ArticleDOI
Abbreviated Breast Magnetic Resonance Imaging (MRI): First Postcontrast Subtracted Images and Maximum-Intensity Projection—A Novel Approach to Breast Cancer Screening With MRI
Christiane K. Kuhl,Simone Schrading,Kevin Strobel,Hans H. Schild,Ralf-Dieter Hilgers,Heribert Bieling +5 more
TL;DR: An MRI acquisitionTime of 3 minutes and an expert radiologist MIP image reading time of 3 seconds are sufficient to establish the absence of breast cancer, with an NPV of 99.8%.
Journal ArticleDOI
Breast cancer mortality in neighbouring European countries with different levels of screening but similar access to treatment: trend analysis of WHO mortality database.
TL;DR: The contrast between the time differences in implementation of mammography screening and the similarity in reductions in mortality between the country pairs suggest that screening did not play a direct part in the reductions in breast cancer mortality.