Journal ArticleDOI
Feather follicle epithelium: a source of enveloped and infectious cell-free herpesvirus from Marek's disease.
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This article is published in Avian Diseases.The article was published on 1970-05-01. It has received 330 citations till now. The article focuses on the topics: Marek's disease & Mardivirus.read more
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Marek's disease vaccine: its implications in biology and medicine.
TL;DR: The objective of preventive medicine is to prevent disease, whether it be an acute infectious disease, a chronic degenerative disease, or a proliferative disease such as cancer.
Journal ArticleDOI
Evidence That Marek's Disease Virus Exists in a Latent State in a Sustainable Fibroblast Cell Line☆
Amin Abujoub,Paul M. Coussens +1 more
TL;DR: Evidence is presented which supports the hypothesis that MDV genomes in MDV OU2 cells are latent and that CHCC-OU2 cells stabilize MDV so that serial in vitro passage does not attenuate the virus.
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West Nile Virus Detection in Nonvascular Feathers from Avian Carcasses
Nicole M. Nemeth,Ginger Young,Kristen L. Burkhalter,Aaron C. Brault,William K. Reisen,Nicholas Komar +5 more
TL;DR: The advantages of using nonvascular feathers over other tissues may outweigh the relatively low detectability of WNV RNA in certain situations such as remote areas lacking resources for acquiring other types of samples or maintaining the cold chain.
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Marek's Disease Virus Late Protein Expression in Feather Follicle Epithelial Cells as Early as 8 Days Postinfection
TL;DR: Though viral DNA can be detected in the skin of infected chickens as early as 6 days postinfection, late viral protein expression, indicative of infectious virus production, occurs 2–3 days after DNA detection, but earlier than previously thought.
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Marek's disease virus immunosuppression alters host cellular responses and immune gene expression in the skin of infected chickens.
TL;DR: Although the overall gene expression pattern was suggestive of a Th1 type immune response, the expression levels of several key immune genes were down regulated in the infected tissues, and the mechanism of MDV-induced immunosuppression appears to be through inhibition of CTL function due to down regulation of CD8 glycoprotein and/or blocking of C TL migration due to decrease expression of cell adhesion molecules.