Journal ArticleDOI
Feather follicle epithelium: a source of enveloped and infectious cell-free herpesvirus from Marek's disease.
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This article is published in Avian Diseases.The article was published on 1970-05-01. It has received 330 citations till now. The article focuses on the topics: Marek's disease & Mardivirus.read more
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Establishment of an Aerosol-Based Marek's Disease Virus Infection Model
Mohamed Faizal Abdul-Careem,Abbas Javaheri-Vayeghan,Sangitha Shanmuganathan,Hamid R. Haghighi,Leah R. Read,Kamran Haq,D. Bruce Hunter,Karel A. Schat,Mohammad Heidari,Shayan Sharif +9 more
TL;DR: An infection model of Marek's disease virus that mimics the natural route of infection is established and will facilitate the studies directed to elucidate MDV-host interaction at the site of virus entry.
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Fluorescent tagging of VP22 in N-terminus reveals that VP22 favors Marek's disease virus (MDV) virulence in chickens and allows morphogenesis study in MD tumor cells.
Sylvie Rémy,Caroline Blondeau,Caroline Blondeau,Yves Le Vern,Monique Lemesle,Jean-François Vautherot,Caroline Denesvre +6 more
TL;DR: Results indicate that MDV morphogenesis in tumor cells is more similar to the morphorgenesis in fibroblastic cells in culture, albeit poorly efficient, than in feather follicle epithelial cells.
Journal ArticleDOI
Marek's disease virus expresses multiple UL44 (gC) variants through mRNA splicing that are all required for efficient horizontal transmission
TL;DR: Two alternative mRNA splice variants were identified by reverse transcription (RT)-PCR analyses, and the encoded proteins were predicted to specify premature stop codons that would lead to gC proteins that lack the transmembrane domain, indicating that all three forms of gC are required for the efficient transmission of MDV in chickens.
Journal ArticleDOI
Field trials of vaccines for Marek's disease.
TL;DR: Herpesvirus vaccines of both turkey and chicken origin were found to be "safe" with respect to their lack of any oncogenic ability in vaccinated birds, but only the turkey herpesviruses offered a satisfactory degree of protection against development of the morbidity and mortality usual with Marek's disease.
Journal ArticleDOI
Relationship Between Levels of Very Virulent MDV in Poultry Dust and in Feather Tips from Vaccinated Chickens
Susan J. Baigent,Lydia Kgosana,Ahmed A. Gamawa,Lorraine P. Smith,Andrew F. Read,Venugopal Nair +5 more
TL;DR: The results confirmed the accuracy and sensitivity of dust DNA extraction and subsequent q-PCR and showed that differences in virus levels between dust samples truly reflect differences in shedding, demonstrating that measurement of the virus in dust can be used to monitor accurately both the infection status of the chickens and environmental contamination by MDV.