Journal ArticleDOI
First-episode schizophrenia with long duration of untreated psychosis: Pathways to care
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TLDR
It seems to be important to educate the social network related to the individual about the importance of early treatment and to identify people earlier, a system of detection must be mobile, easily accessible and attentive to early symptoms of psychosis.Abstract:
Background The early course of illness in first-episode schizophrenia was examined with special emphasis on the duration of untreated psychosis and pathways to care. Method The consecutively admitted individuals (n = 34) were assessed on premorbid functioning, duration of untreated psychosis, global functioning, symptoms and social network. To clarify the obstacles for receiving earlier treatment, 17 case histories with long duration of untreated psychosis were intensively studied. Results The duration of untreated psychosis was on average very long (130 weeks), the median value was 54 weeks. The long duration of untreated psychosis group (> 54 weeks) had greater deterioration in the premorbid phase, a weaker social network and were more withdrawn than the short duration of untreated psychosis group ( Conclusions In order to identify people earlier, a system of detection must be mobile, easily accessible and attentive to early symptoms of psychosis. It seems to be important to educate the social network related to the individual about the importance of early treatment.read more
Citations
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Journal ArticleDOI
Relationship Between Duration of Untreated Psychosis and Outcome in First-Episode Schizophrenia: A Critical Review and Meta-Analysis
TL;DR: Shorter duration of untreated psychosis was associated with greater response to antipsychotic treatment, as measured by severity of global psychopathology, positive symptoms, negative symptoms, and functional outcomes.
Journal ArticleDOI
The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches
Jeffrey A. Lieberman,Diana O. Perkins,Aysenil Belger,Miranda Chakos,Fred Jarskog,Kalina Boteva,John H. Gilmore +6 more
TL;DR: Because the clinical deterioration that occurs in schizophrenia may actually begin in the prepsychotic phase, early identification and intervention may favorably alter the course and outcome of schizophrenia.
Journal ArticleDOI
Duration of untreated psychosis: a critical examination of the concept and its importance.
Ross M.G. Norman,Ashok Malla +1 more
TL;DR: Evidence thus far suggests that DUP may be related to ease of reducing psychotic symptoms once treatment begins for first episode patients, but there is no evidence of a relationship to likelihood of relapse.
Journal ArticleDOI
The initial prodrome in schizophrenia: searching for naturalistic core dimensions of experience and behavior.
Paul Møller,Ragnhild Husby +1 more
TL;DR: It is argued that the findings, the phenomena, and their significance in prodromes are valid because they are logical and coherent in light of clinical experience as well as the empirical literature of a full century.
Journal ArticleDOI
Early Intervention for Psychosis
Max Marshall,John Rathbone +1 more
TL;DR: Early detection and phase-specific treatment may both be offered as supplements to standard care or may be provided through a specialized early intervention team.
References
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Journal ArticleDOI
The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia
TL;DR: Review of five studies involving the PANSS provided evidence of its criterion-related validity with antecedent, genealogical, and concurrent measures, its predictive validity, its drug sensitivity, and its utility for both typological and dimensional assessment.
Journal ArticleDOI
Measurement of Premorbid Adjustment in Chronic Schizophrenia
TL;DR: The Premorbid Adjustment Scale has been found to be useful in identifying patients likely to become chronically hospitalized or at high risk for readmission, and may also serve as a possible predictor of patients with brain abnormalities on a computerized tomography scan.
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EPPIC: An Evolving System of Early Detection and Optimal Management
TL;DR: A framework for preventive intervention in early psychosis is outlined, based on more than a decade of experience initially gained within a first-generation model, a comprehensive "real-world" model of care targeting the multiple clinical foci underpinning the preventive task.
Journal ArticleDOI
Duration of psychosis and outcome in first-episode schizophrenia.
Antony Loebel,Jeffrey A. Lieberman,Jose Alvir,David Mayerhoff,Stephen Geisler,Sally Szymanski +5 more
TL;DR: Duration of psychosis before treatment may be an important predictor of outcome in first-episode schizophrenia, and is significantly associated with time to remission as well as with level of remission.
Journal ArticleDOI
Awareness of Illness in Schizophrenia and Schizoaffective and Mood Disorders
Xavier F. Amador,Michael Flaum,Nancy C. Andreasen,David H. Strauss,Scott Yale,Scott C. Clark,Jack M. Gorman +6 more
TL;DR: It is suggested that severe self-awareness deficits are a prevalent feature of schizophrenia, perhaps stemming from the neuropsychological dysfunction associated with the disorder, and are more common in schizophrenia than in other psychotic disorders.