Journal ArticleDOI
Flow characteristics in models of arterial stenoses. II. Unsteady flow.
Donald F. Young,Frank Y. Tsai +1 more
TLDR
It is shown that three dimensionless parameters can be used to characterize the unsteady flow in a stenosis and the effect of unsteadiness is investigated experimentally using axisymmetric and nonsymmetric models.About:
This article is published in Journal of Biomechanics.The article was published on 1973-07-01. It has received 698 citations till now. The article focuses on the topics: Flow coefficient & Open-channel flow.read more
Citations
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Journal ArticleDOI
Numerical simulation and experimental validation of blood flow in arteries with structured-tree outflow conditions.
TL;DR: Comparison between the simulations and magnetic resonance measurements in the ascending aorta and nine peripheral locations in one individual shows excellent agreement between the two.
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Quantitative coronary arteriography: estimation of dimensions, hemodynamic resistance, and atheroma mass of coronary artery lesions using the arteriogram and digital computation.
TL;DR: A method of segmental artery analysis has been developed to maximize the information obtained from coronary arteriograms and the accuracy and variability of the different steps involved in lesion analysis have been determined.
Journal ArticleDOI
Computer simulation of arterial flow with applications to arterial and aortic stenoses.
TL;DR: Comparison with the published experimental data suggests that the model is capable of simulating arterial flow under normal flow conditions as well as conditions of stenotic obstructions in a satisfactory manner.
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Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilatation. I. Physiologic basis and experimental validation.
TL;DR: The results from 145 images obtained at rest, during exercise or after coronary vasodilators in dogs with mild to severe coronary stenoses demonstrate the following: the ratio of maximal flow in a normal to stenotic coronary artery must be at least 2:1 before defects appear in the myocardial perfusion image of thallium-201.
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Pressure-flow characteristics of coronary stenoses in unsedated dogs at rest and during coronary vasodilation.
TL;DR: The augmented separation loss following coronary vasodilation probably was due to dilation of the epicardial artery adjacent to the fixed stenotic segment which caused more severe relative percent narrowing and a larger divergence angle at the distal end of the stenosis, the primary geometric determinants of separation losses.
References
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Method for the calculation of velocity, rate of flow and viscous drag in arteries when the pressure gradient is known
TL;DR: The experiments of McDonald and his co-workers have shown that in the larger arteries of the rabbit and the dog there is a reversal of the flow, and the simple mathematical treatment has strong similarities with the theory of the distribution of alternating current in a conductor of finite size.
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Atheroma and arterial wall shear. Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis.
TL;DR: It appears that wall shear rate may be a major controlling factor in the development of atheromatous lesions in man and in animals and a net flux of cholesterol from blood to wall cannot account for the observed normally occurring (quasi-steady state) and experimentally induced atheroma.
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Acute Vascular Endothelial Changes Associated with Increased Blood Velocity Gradients
TL;DR: The purpose of this study is to quantify the acute changes in endothelial histology that are associated with an induced increase in blood velocity and to establish the “normal” endothelial cell population density as a function of stress exposure.
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Certain Histological and Chemical Responses of the Vascular Interface to Acutely Induced Mechanical Stress in the Aorta of the Dog
TL;DR: The flux of Evans blue dye into the intimal region increased with pressure or wall strain, with shearing stress, and with increased turbulence, and was found to be most heavy in areas of total cellular erosion.