Journal ArticleDOI
Functional relationship between the pars intermedia and ACTH secretion in the rat.
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The incorporation of thymidine- 3H into the various cell types of the adenohypophysis has been studied using autoradiography and histological changes were restricted to the pars intermedia, where numerous dark cells were observed only after adrenalectomy.Abstract:
In order to identify the cell type responsible for ACTH production in the rat adenohypophysis, the incorporation of thymidine- 3H into the various cell types of the adenohypophysis has been studied using autoradiography. Sections were examined 1 month following adrenalectomy, when ACTH secretion is greatly increased, and 1 month following the daily administration of cortisol, when ACTH secretion is suppressed. Only 1 cell type, restricted to the pars intermedia, responded to altered levels of ACTH secretion with both an increase in label index following adrenalectomy and a decrease in label index following cortisol administration. Histological changes were restricted to the pars intermedia, where numerous dark cells were observed only after adrenalectomy. Following adrenalectomy, increases in weight were restricted to the colloid and the pars intermedia. Since no changes in plasma or hypophysial MSH content were found, the histological and autoradiographic changes do not simply reflect alterations in MSH ...read more
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Journal ArticleDOI
The opiomelanotropinergic neuronal and endocrine systems.
TL;DR: The anatomy, physiology and biochemistry of opiomelanotropinergic neurons are reviewed and the implications of multi-neurotransmitter and multi-hormone neurons and cells are discussed.
Journal ArticleDOI
[The network of the folliculo-stellate cells and the follicles of the adenohypophysis in the rat (pars distalis)].
TL;DR: Electron microscopic investigation of the rat anterior pituitary reveals a cellular network composed of agranular cells, present in numerous species, showing a typical and differentiated cytology, and close relationships with the interstitial medium.
Journal ArticleDOI
Corticotrophin-like peptides in the rat pituitary.
Journal ArticleDOI
Adrenocorticotropin production by the intermediate lobe of the rat pituitary. An electron microscopic-immunohistochemical study
TL;DR: There were distinct immunohistochemical differences between the pars intermedia and anterior lobe ACTH cells, which suggests that ACTH may not be packaged or condensed in the Golgi region of the latter.
Journal ArticleDOI
Radioautographic study of the rat brain and pituitary after injection of 3H dexamethasone.
TL;DR: The results obtained in the present study suggest essentially an action of dexamethasone in the medial basal hypothalamus and at the level of the pituitary of adrenalectomized male rats injected with 3H-dexamethAsone.
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