Open AccessJournal Article
Further evidence for gastroprotection induced by aluminium hydroxide in the rat.
Szelenyi I,Postius S +1 more
TLDR
Al(OH)3 was able to counteract the damaging effect of the compounds mentioned and may be explained by the release of vasodilating prostaglandins into the submucosa and by the slight spasmolytic effect of aluminium that also contributes to the improvement of the mucosal blood supply.Abstract:
The effect of aluminium hydroxide on the development of gastric mucosal lesions induced by microcirculatory disturbances was investigated in the rat. Aluminium hydroxide dose-dependently inhibited the serotonin-induced gastric damages. Carbachol give subcutaneously intensified the development both of ethanol-produced gastric erosions and of indometacin-induced lesions. Al(OH)3 was able to counteract the damaging effect of the compounds mentioned. The gastroprotective effect of Al(OH)3 may be explained by the release of vasodilating prostaglandins into the submucosa; and by the slight spasmolytic effect of aluminium that also contributes to the improvement of the mucosal blood supply.read more
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Alimentary tract and pancreas. Stimulation of mucosal prostaglandin synthesis in human stomach and duodenum by antacid treatment.
TL;DR: In this paper, the effect of low-dose antacid treatment on mucosal prostaglandin metabolism was studied in 15 healthy volunteers for three weeks, where a daily dose of 46 mmol (= 138 mval) Al(OH)3 and 42 mmol (= 84 mval), Mg(OH), with a titrated in vitro neutralising capacity of 272 mval of H+ was given for 3 weeks.
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Antacids: new perspectives in cytoprotection.
TL;DR: Antacids have advantages over the H2 blockers in protecting the gastric mucosa against alcohol-induced necrosis and in preventing stress-induced ulcers in critically ill patients and new potential clinical applications for antacids are found.
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Effects of milk, prostaglandin, and antacid on experimentally induced duodenitis in the rat. Use of myeloperoxidase as an index of inflammation.
TL;DR: Measurement of myeloperoxidase activity is a sensitive and potentially useful estimate of duodenal injury that can be valuable in assessing ulcerogenesis and healing and test the effectiveness of known gastric protective agents.
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Putative mechanisms of cytoprotective effect of certain antacids and sucralfate
TL;DR: It is likely that additional mechanisms and mediators other than prostaglandins, such as nonprotein sulfhydryls, also are involved in gastric cytoprotection arising from aluminum-containing antacids.
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Effect of antacid treatment on endogenous prostaglandin synthesis in human antral and duodenal mucosa.
TL;DR: It is concluded that long-term antacid treatment may alter the prostaglandin pattern formed by gastroduodenal mucosa and this may be related to its therapeutic effect.