Journal ArticleDOI
Galactose toxicity in the rat as a model for premature ovarian failure: an experimental approach readdressed.
Santu Bandyopadhyay,J. Chakrabarti,Swagatam Banerjee,A.K. Pal,S.K. Goswami,Baidyanath Chakravarty,Syed N. Kabir +6 more
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TLDR
Experimental galactose toxicity may serve as a model for exploring some of the basic tenets of POF.Abstract:
Background The pathophysiological mechanisms underlying premature ovarian failure (POF) are largely unknown. Our objective was to develop a working animal model to explore the pathogenesis of POF. Since galactosaemic women eventually develop POF, we evaluated the potential of experimental galactose toxicity as the proposed model. Methods Pregnant rats were fed pellets supplemented with or without 35% galactose from day 3 of conception continuing through weaning of the litters. Female offspring were evaluated for serum levels of galactose and galactose-1-phosphate, growth rate, onset of puberty, reproductive cyclicity, ovarian complement of follicles, hypothalamo-pituitary-ovarian function and follicular response to gonadotrophins. Results Galactose toxicity delayed the onset of puberty and developed a state of hypergonadotrophic hypoestrogenism. The characteristic low FSH levels at weaning followed by pubertal spurts of gonadotrophins and estradiol (E(2)) secretion of the controls was replaced by a sustained high level of FSH and a low level of E(2) under galactose toxicity. The ovary developed with apparently normal or deficient complement of follicles. Ovarian response to exogenous gonadotrophin stimulation was blunted, but the response improved significantly when the stimulation was preceded by pituitary desensitization. Conclusion Experimental galactose toxicity may serve as a model for exploring some of the basic tenets of POF.read more
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Diet and Fertility: A Review
TL;DR: A complete picture of the role of nutrition on fertility is far from complete, but much progress has been made and the most salient gaps in the current evidence include jointly considering female and male diets and testing the most consistent findings in randomized trials.
Journal ArticleDOI
Transplantation of Human Menstrual Blood Stem Cells to Treat Premature Ovarian Failure in Mouse Model
TL;DR: The results revealed that the HuMenSCs could survive within POF mouse ovaries for at least 14 days in vivo, and the mesenchymal stem cell properties and in vivo survival of Hu menSCs make them ideal seed cells for stem cell transplantation in the treatment of POF.
Journal ArticleDOI
Exosomal miR-10a derived from amniotic fluid stem cells preserves ovarian follicles after chemotherapy.
Guan-Yu Xiao,Chun-Chun Cheng,Yih-Shien Chiang,Winston T.K. Cheng,Winston T.K. Cheng,I-Hsuan Liu,Shinn-Chih Wu +6 more
TL;DR: It is demonstrated that AFSC-derived exosomes recapitulate the anti-apoptotic effect of AFSCs on CTx-damaged granulosa cells (GCs), which are vital for the growth of ovarian follicles, and that miR-10a has potential as a novel therapeutic agent for the treatment of POF.
Journal ArticleDOI
A prospective study of dairy foods intake and anovulatory infertility
TL;DR: High intake of low-fat dairy foods may increase the risk of anovulatory infertility whereas intake of high-fat Dairy foods may decrease this risk, and lactose may not affect fertility within the usual range of intake levels in humans.
Journal ArticleDOI
Galactose toxicity in animals.
TL;DR: This contemporary review takes a unique approach to present an overview of galactose toxicity resulting from the three known congenital disorders ofGalactose metabolism and from experimental hypergalactosemia to update the reader about research progress on animal models, as well as advances in clinical management and therapies of these disorders.
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Premature ovarian failure
Deepti Goswami,Gerard S. Conway +1 more
TL;DR: The past 2 years have seen progress in the understanding of the process of premature ovarian failure with identification of molecular causes and clarification of the auto-immune targets within the ovary.
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Reproductive endocrinology, surgery, and technology
TL;DR: The Reproductive Axis: Formation and Maturation; Reproductive Roles of Eiconsanoids Hormonal Assay Methodology; and Human Infertility: Present and Future Prospects.
Journal ArticleDOI
Long-term prognosis in galactosaemia: results of a survey of 350 cases.
TL;DR: An international survey of the long term results of treating galactosaemia has shown poor results, but these do not seem to be related to any of the relevant variables studied, for example delayed diagnosis or poor dietary compliance.