Journal ArticleDOI
Genetic hitchhiking in spatially extended populations.
Reads0
Chats0
TLDR
When a mutation with selective advantage s spreads through a panmictic population, it may cause two lineages at a linked locus to coalesce; the probability of coalescence is exp(-2rT), where T∼log(2Ns)/s is the time to fixation, N is the number of haploid individuals, and r is the recombination rate.About:
This article is published in Theoretical Population Biology.The article was published on 2013-08-01. It has received 55 citations till now. The article focuses on the topics: Population & Coalescence (physics).read more
Citations
More filters
Journal ArticleDOI
On the accumulation of deleterious mutations during range expansions
Stephan Peischl,Stephan Peischl,Stephan Peischl,Isabelle Dupanloup,Isabelle Dupanloup,Mark Kirkpatrick,Laurent Excoffier,Laurent Excoffier +7 more
TL;DR: In this paper, the authors investigate the effect of spatial range expansions on the evolution of fitness when beneficial and deleterious mutations cosegregate, and they find that the expansion load can persist and represent a major fraction of the total mutation load for thousands of generations after the expansion.
Posted Content
On the accumulation of deleterious mutations during range expansions
Stephan Peischl,Stephan Peischl,Stephan Peischl,Isabelle Dupanloup,Isabelle Dupanloup,Mark Kirkpatrick,Laurent Excoffier,Laurent Excoffier +7 more
TL;DR: It is found that deleterious mutations accumulate steadily on the wave front during range expansions, thus creating an expansion load that can persist and represent a major fraction of the total mutation load for thousands of generations after the expansion.
Journal ArticleDOI
Acceleration of evolutionary spread by long-range dispersal.
TL;DR: In this article, a simple iterative scaling approximation supported by simulations and rigorous bounds that accurately predicts evolutionary spread is presented, which is determined by a trade-off between frequency and potential effectiveness of long-distance jumps.
Journal ArticleDOI
Estimating the parameters of background selection and selective sweeps in Drosophila in the presence of gene conversion.
TL;DR: Developing models of selection at linked sites to explain the observed negative relation between the level of nearly neutral variability in Drosophila genes and their protein sequence divergence from a related species shows that selective sweeps are the main determinants of this pattern.
Journal ArticleDOI
The Role of Standing Variation in Geographic Convergent Adaptation.
Peter L. Ralph,Graham Coop +1 more
TL;DR: This article explores how standing genetic variation contributes to convergent genetic responses in a geographically spread population, and derives the geographic scale over which an allele dominates and the proportion of adaptive alleles that arise from standing variation.
References
More filters
Book
The theory of stochastic processes
David Cox,Hilton D. Miller +1 more
TL;DR: This book should be of interest to undergraduate and postgraduate students of probability theory.
Book
A second course in stochastic processes
Samuel Karlin,Howard E Taylor +1 more
TL;DR: A First Course Algebraic methods in Markov Chains Ratio Theorems of Transition Probabilities and Applications Sums of Independent Random Variables as a Markov Chain Order Statistics, Poisson Processes, and Applications Continuous Time Markov chains Diffusion Processes Compounding Stochastic Processes Fluctuation Theory of Partial Sum of Independent Identically Distributed Random Variable Queueing Processes Miscellaneous Problems Index as discussed by the authors.
Journal ArticleDOI
The hitch-hiking effect of a favourable gene.
John Maynard Smith,John Haigh +1 more
TL;DR: If the selective coefficients at the linked locus are small compared to those at the substituted locus, it is shown that the probability of complete fixation at the links is approximately exp (− Nc), where c is the recombinant fraction and N the population size.
Journal ArticleDOI
Genetic Consequences of Range Expansions
TL;DR: Interestingly, most of these patterns had been previously attributed to distinct selective processes, showing that taking into account the dynamic nature of a species range can lead to a paradigm shift in the authors' perception of evolutionary processes.