Journal ArticleDOI
Gentamicin: Clinical Use with Carbenicillin and In-Vitro Studies with Recent Isolates of Pseudomonas aeruginosa
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The susceptibility to gentamicin of 33 isolates of Pseudomonas aeruginosa recovered at Memorial Sloan-Kettering Cancer Center before April, 1969, was compared to the susceptibility of 72 organisms recovered in the following 18 months, finding no significant difference in patterns of sensitivity.Abstract:
The susceptibility to gentamicin of 33 isolates of Pseudomonas aeruginosa recovered at Memorial Sloan-Kettering Cancer Center before April, 1969, was compared to the susceptibility of 72 organisms recovered in the following 18 months. No significant difference in patterns of sensitivity was observed; 96 of 105 organisms (91%) were inhibited at or below 3.12 ig/ml. Twenty of 23 isolates from blood cultures were still inhibited at or below 3.12 pIg/ml, despite the fact that they were recovered from patients receiving gentamicin for periods exceeding four days. Of 46 organisms isolated from blood cultures during 19691970, all but two were inhibited by concentrations of 1.56 vtg/ml of gentamicin and 50 [tg/ml of carbenicillin. Fifteen cases of bacteremia due to Pseudomonas were treated with a combination of these two drugs; infection was cured in seven and controlled in two. Success in therapy was associated with remission in leukemia or control of the underlying disease.read more
Citations
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Gram-Negative Rod Bacteremia: Microbiologic, Immunologic, and Therapeutic Considerations
TL;DR: Both clinical and experimental evidence suggest that active or passive immunization with endotoxin components or antigens similar to Gram-negative polysaccharides may be protective in patients with the most adverse host factors.
Journal ArticleDOI
Pseudomonas bacteremia: Review of 108 cases
TL;DR: A reassessment is needed to evaluate the relationship between the in vitro action and the effectiveness of antibiotics in the treatment of Pseudomonas infection and the use of gentamicin, carbenicillin and colistin in these bacteremia.
Journal ArticleDOI
Pseudomonas Aeruginosa Infections
L. S. Young,D. Amstrong +1 more
TL;DR: Agarwal et al. as discussed by the authors published a paper on Pseudomonas Aeruginosa Infections in Clinical Laboratory Sciences, Vol. 3, No. 3 (CRLS), pp. 291-347.
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Antibiotic Susceptibility Testing of Pseudomonas aeruginosa: Selection of a Control Strain and Criteria for Magnesium and Calcium Content in Media
TL;DR: It is recommended that Mueller-Hinton media contain 20-35 mg of Mg++ and 50-100 mg of Ca++ per liter and that Pseudomonas aeruginosa should be assured by the manufacturer before sale and by the clinical laboratory during use.
Journal ArticleDOI
Simultaneous antibiotic levels in “breakthrough” gram-negative rod bacteremia☆
TL;DR: Of 237 cases of gram-negative rod bacteremia observed at the UCLA Medical Center during a 12 month period, 52 (22 per cent) occurred while the patient was receiving antibiotics which inhibited the infecting organism by disc diffusion tests.
References
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Book
Manual for the identification of medical bacteria.
S. T. Cowan,K. J. Steel +1 more
TL;DR: Manual for the identification of medical bacteria as discussed by the authors, Manual for identification of Medical bacteria, مرکز فناوری اطلاعات و اشعران رسانی
Journal Article
Manual For The Identification Of Medical Bacteria
TL;DR: A manual for the identification of medical bacteria is presented for the first time in a systematic fashion.
Journal Article
An inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics.
Journal ArticleDOI
Infectious Complications of Neoplastic Disease
TL;DR: Improved methods such as serology, open lung biopsy, and fiberoptic bronchoscopy have allowed for earlier diagnosis and treatment of opportunistic infections, and the development of empiric antibiotic regimens have improved the outcome in the febrile neutropenic patient.