Group Sequential Design for Randomized Phase III Trials under the Weibull Model
Jianrong Wu,Xiaoping Xiong +1 more
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A parametric sequential test is proposed under the Weibull model that is asymptotically normal with an independent increment structure and applies the Brownian motion property of the test statistic and sequential conditional probability ratio test methodology.Abstract:
In this article, a parametric sequential test is proposed under the Weibull model. The proposed test is asymptotically normal with an independent increment structure. The sample size for a fixed sample test is derived for the purpose of group sequential trial design. In addition, a multi-stage group sequential procedure is given under the Weibull model by applying the Brownian motion property of the test statistic and sequential conditional probability ratio test methodology.read more
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Excellent Outcome for Pediatric Patients With High-Risk Hodgkin Lymphoma Treated With Brentuximab Vedotin and Risk-Adapted Residual Node Radiation
Monika L. Metzger,Monika L. Metzger,Michael P. Link,Amy L. Billett,Jamie E. Flerlage,Jamie E. Flerlage,John T. Lucas,Belinda N. Mandrell,Matthew J. Ehrhardt,Matthew J. Ehrhardt,Nickhill Bhakta,Nickhill Bhakta,Torunn I. Yock,Alison M. Friedmann,Pedro A. de Alarcon,Sandra Luna-Fineman,Eric Larsen,Sue C. Kaste,Sue C. Kaste,Barry L. Shulkin,Zhaohua Lu,Chen Li,Susan M. Hiniker,Sarah S. Donaldson,Melissa M. Hudson,Melissa M. Hudson,Matthew J. Krasin +26 more
TL;DR: Brentuximab vedotin, an effective anti-CD30 antibody-drug conjugate approved for use in adults with classical Hodgkin lymphoma (HL), was introduced in this frontline trial to reduce prescrib...
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Group Sequential Survival Trial Design and Monitoring Using the Log-Rank Test.
Jianrong Wu,Xiaoping Xiong +1 more
TL;DR: A sample size formula for the two-sample log-rank test under the proportional hazards model is proposed that provides more accurate sample size calculation for unbalanced survival trial designs.
References
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