Hematological changes in mice experimentally infected with Trypanosoma Cruzi
Jarbas E. Cardoso,Zigman Brener +1 more
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TLDR
Mice inoculated with trypanosoma cruzi display an intense thrombocytopenia which is more severe in animals infected with the Y than CL strain and is likely to be related to more general phenomena affecting the host rather than to direct damage of platelets or precursor cells by parasitism.Abstract:
Mice inoculated with trypanosoma cruzi display an intense thrombocytopenia which is more severe in animals infected with the Y than CL strain. In animals inoculated with a T. cruzi strain which induces chronic infection (Colombiana), the number of platelets decreases as parasitemia ascends, and then reverts to normal values as soon as the acute infection merges into the chronic phase. The mechanisms involved in the thrombocytopenia are still obscure and are likely to be related to more general phenomena affecting the host rather than to direct damage of platelets or precursor cells by parasitism. Anemia and leukopenia are also present in T. cruzi infected mice.read more
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Journal ArticleDOI
A developmentally regulated neuraminidase activity in Trypanosoma cruzi
TL;DR: Erythrocytes from infected mice with T. cruzi parasitemia were agglutinated by peanut lectin and the hemagglutination titer was correlated with the degree of Parasitemia, but the best substrate was the protein orosomucoid.
Journal ArticleDOI
The trans-sialidase from Trypanosoma cruzi induces thrombocytopenia during acute Chagas' disease by reducing the platelet sialic acid contents.
María Virginia Tribulatti,Juan Mucci,Nico van Rooijen,María Susana Leguizamón,Oscar Campetella +4 more
TL;DR: The hypothesis that the trans-sialidase is the virulence factor that, after depleting the sialic acid content of platelets, induces the accelerated clearance of the platelets that leads to the thrombocytopenia observed during acute Chagas' disease is strongly supported.
Journal ArticleDOI
A neuraminidase from Trypanosoma cruzi removes sialic acid from the surface of mammalian myocardial and endothelial cells.
TL;DR: Infective forms of T. cruzi can chemically modify the surfaces of myocardial and vascular endothelial cells by desialylation, which may play a role in the initial interaction of this parasite with these important target cells of the host cardiovascular system.
Journal ArticleDOI
Acute Trypanosoma cruzi infection is associated with anemia, thrombocytopenia, leukopenia, and bone marrow hypoplasia: reversal by nifurtimox treatment
TL;DR: This is the first report showing that acute T. cruzi infection results in profound alterations of the hematopoietic system and that these alterations can be prevented by nifurtimox treatment.
Journal ArticleDOI
Effects of cyclooxygenase inhibitors on parasite burden, anemia and oxidative stress in murine Trypanosoma cruzi infection.
Vera Lúcia Hideko Tatakihara,Rubens Cecchini,Celso Luiz Borges,Aparecida Donizette Malvezi,Viviane K. Graça-de Souza,Sueli Fumie Yamada-Ogatta,Luiz Vicente Rizzo,Phileno Pinge-Filho +7 more
TL;DR: It is demonstrated that inducible cyclooxygenase-mediated prostaglandin production is a key chemical mediator in the control of parasite burden and erythrocyte oxidative stress during T. cruzi infection in C57BL/6 and BALB/c mice.