O
Oscar Campetella
Researcher at National Scientific and Technical Research Council
Publications - 70
Citations - 3178
Oscar Campetella is an academic researcher from National Scientific and Technical Research Council. The author has contributed to research in topics: Trypanosoma cruzi & Sialic acid. The author has an hindex of 35, co-authored 69 publications receiving 2873 citations. Previous affiliations of Oscar Campetella include Mayo Clinic & National University of General San Martín.
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Journal ArticleDOI
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.
Daniela A. Bermejo,Shaun W. Jackson,Shaun W. Jackson,Melisa Gorosito-Serrán,Eva V. Acosta-Rodríguez,Maria C. Amezcua-Vesely,Blythe D. Sather,Blythe D. Sather,Akhilesh Kumar Singh,Akhilesh Kumar Singh,Socheath Khim,Socheath Khim,Juan Mucci,Denny Liggitt,Oscar Campetella,Mohamed Oukka,Mohamed Oukka,Adriana Gruppi,David J. Rawlings,David J. Rawlings +19 more
TL;DR: It is found that exposure to parasite-derived trans-sialidase in vitro was sufficient to trigger modification of the cell-surface mucin CD45, which led to signaling dependent on the kinase Btk and production of IL-17F via a transcriptional program independent of the transcription factors RORγt and Ahr.
Journal ArticleDOI
Structural basis of sialyltransferase activity in trypanosomal sialidases.
Alejandro Buschiazzo,Gisele A. Tavares,Gisele A. Tavares,Oscar Campetella,Silvia Spinelli,Marfa L. Cremona,Gastón Paris,Maria Fernanda Amaya,Alberto C.C. Frasch,Pedro M. Alzari +9 more
TL;DR: The crystal structure of the closely related Trypanosoma rangeli sialidase and its complex with inhibitor is reported, illustrating how a glycosidase scaffold can achieve efficient glycosyltransferase activity and provide a framework for structure‐based drug design.
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Tandem Amino Acid Repeats From Trypanosoma cruzi Shed Antigens Increase the Half-Life of Proteins in Blood
TL;DR: It is shown that repeats present on T. cruzi shed proteins increase trans-sialidase half-life in blood from 7 to almost 35 hours, and antigens 13 and SAPA also increase the persistence in blood of chimeric glutathione S-transferases, thus suggesting that this effect is inherent to these repeats and independent of the carrier protein.
Journal ArticleDOI
Thymocyte depletion in Trypanosoma cruzi infection is mediated by trans-sialidase-induced apoptosis on nurse cells complex
Juan Mucci,Alejandra Hidalgo,Esteban Mocetti,Pablo Argibay,M. Susana Leguizamón,Oscar Campetella +5 more
TL;DR: Supporting evidence is reported that TS is the virulence factor from T. cruzi responsible for the thymic alterations via apoptosis induction on the nurse cell complex, and that TS-neutralizing Abs elicitation during infection is associated with the reversion to thymi normal parameters.
Journal ArticleDOI
Differential Expression of a Virulence Factor,the trans-Sialidase, by the Main Trypanosoma cruzi Phylogenetic Lineages
Marikena G. Risso,Gloria B. Garbarino,Esteban Mocetti,Oscar Campetella,Stella M. Gonzlez Cappa,Carlos A. Buscaglia,Susana M. Leguizamn +6 more
TL;DR: Trans-sialidase becomes the first T. cruzi virulence factor identified that is differentially expressed by the main parasite groups and that contributes to their contrasting behaviors.