Journal ArticleDOI
Hemoglobin variants in India
TLDR
The association of Hb E with beta thalassaemia G6PD deficiency has been established and the relationship with other environmental factors, like malaria, is not yet clear.Abstract:
The occurrence of different types of hemoglobin variants in India has been well-documented in urban populations and in certain tribal areas. Beta-thalassaemia and hemoglobins D, E, H, S, and rare variants like Hb Lepore, have been found in varying percentages. There is a higher incidence of Hb E in the Eastern region and of Hb D in certain Northern populations. The association of Hb E with beta thalassaemia G6PD deficiency has been established. The relationship with other environmental factors, like malaria, is not yet clear.read more
Citations
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Journal ArticleDOI
Hemoglobinopathies in India
TL;DR: Hemglobin variants, thalassemia, hereditary persistence of fetal herroglobin and compound disorders reported from India are listed in tabular form by state and population.
Journal ArticleDOI
Molecular studies of haemoglobin-E in tribal populations of Tripura
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Interaction of different hemoglobinopathies in Eastern India with a view to establish genotype-phenotype correlation.
Swapan K Das,Madhusnata De,Dilip K. Bhattacharya,Bani Sengupta,Nikhilesh Das,Geeta Talukder,Geeta Talukder +6 more
TL;DR: A database of hemoglobinopathy mutations for the population of Eastern India is created which will facilitate prenatal diagnosis and counseling and establish the origin of mutation.
Journal ArticleDOI
Beta Globin Gene and Related Diseases: A Review
Swapan K Das,Geeta Talukder +1 more
TL;DR: Clinical or phenotypic diversity of β-thalassaemia and other β- haemoglobinopathies suggest that it is determined by layer upon layer of complexity.
Journal ArticleDOI
Biology of the people of Sikkim, India. 1. Studies on the variability of genetic markers
M. K. Bhasin,H. Walter,S. M. S. Chahal,Veena Bhardwaj,K. Sudhakar,Heidi Danker-Hopfe,Angela Dannewitz,Indera O. Singh,Vivek Bhasin,Anu Prabha Shil,Madhu B. Sharma,Devala Wadhavan +11 more
TL;DR: Genetic distance analysis revealed a cluster pattern, which reflects to a great extent the ethnohistoric relations among the populations under study, and shows a considerable interpopulational variability.
References
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Protection Afforded by Sickle-cell Trait Against Subtertian Malarial Infection
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TL;DR: Whether there were migrations to prehistoric Africa from other continents, possibly Asia, is speculated, supported by the observation that the tall, broadshouldered skeleton of the modern Bantu appears only in Neolithic excavations, whereas the types found in older strata are more slender.
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Favism and thalassaemia in Sardinia and their relationship to malaria
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On consanguineous marriages and the genetic load
TL;DR: The genetic load as disclosed by inbreeding is computed for perinatal mortality, major malformations and pooling these together and A+B, the measure of the number of lethal equivalents per gamete, is found to be at variance with other reports.