Journal ArticleDOI
High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on polysaccharide-type chiral stationary phases.
TLDR
The use of the column-switching technique is demonstrated to achieve the resolution of some drugs with multiple chiral centers using polysaccharide-type chiral stationary phases.About:
This article is published in Journal of Chromatography A.The article was published on 2001-01-12. It has received 114 citations till now. The article focuses on the topics: Enantiomer.read more
Citations
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Journal ArticleDOI
Solvent versatility of immobilized 3,5-dimethylphenylcarbamate of amylose in enantiomeric separations by HPLC
Tong Zhang,Christophe Kientzy,Pilar Franco,Atsushi Ohnishi,Yasuhiro Kagamiharb,Hidehiro Kurosawa +5 more
TL;DR: The option to use a wide range of solvents, especially the "non-standards" ones, in the mobile phase enables the enhancement of chiral separation methods in terms of enantioselectivity, resolution, analysis time, sample injection and sample solubility.
Journal ArticleDOI
Effects of alcohol mobile-phase modifiers on the structure and chiral selectivity of amylose tris(3,5-dimethylphenylcarbamate) chiral stationary phase.
Tao Wang,Robert M. Wenslow +1 more
TL;DR: Solid-state NMR (1H/13C CPMAS) was utilized to identify and compare structural differences in Chiralpak AD caused by the various alcohol mobile-phase modifiers, many of which were not studied in the previous publication.
Journal ArticleDOI
Enantiomer resolution screening strategy using multiple immobilised polysaccharide-based chiral stationary phases.
TL;DR: An understanding is established of the global enantioselective profiles of this series of chiral stationary phases (CSPs) that exhibit an exceptional level of complementary chiral recognition characteristics by applying common screening and method optimisation strategies.
Journal ArticleDOI
Optimization strategies for HPLC enantioseparation of racemic drugs using polysaccharides and macrocyclic glycopeptide antibiotic chiral stationary phases
Hassan Y. Aboul-Enein,Imran Ali +1 more
TL;DR: This review discusses the optimization of HPLC conditions for the chiral resolution of racemic drugs on polysaccharides and macrocyclic glycopeptide antibiotic chiral stationary phases (CSPs).
Journal ArticleDOI
Advances in chiral separations of small peptides by capillary electrophoresis and chromatography
TL;DR: Efforts are made to explain the chiral recognition mechanisms, which will be helpful in understanding existing and developing new stereoselective analyses and the demand of enantiomeric resolution of all naturally occurring and synthetic peptides is concluded.
References
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Journal ArticleDOI
Chromatographic resolution : XI. Controlled chiral recognition of cellulose triphenylcarbamate derivatives supported on silica gel
TL;DR: The inductive effect of substituents greatly influenced the optical resolution ability when they were at the 3- or 4-position 2-substituted derivatives showed a low degree of resolution.
Journal ArticleDOI
Resolution by high-performance liquid chromatography using polysaccharide carbamates and benzoates as chiral stationary phases
Yoshio Okamoto,Yuriko Kaida +1 more
TL;DR: In this article, triscarbamates of the polysaccharides as chiral stationary phases (CSPs) for HPLC are extensively discussed, including cellulose and amylose.
Book
A practical approach to chiral separations by liquid chromatography
TL;DR: In this article, an introduction to enantioseparation by liquid chromatography regulatory implications and chiral separations modelling enantiodifferentiation in chiral chromatography enantiomer separation using tailormade phases prepared by molecular imprinting cyclodextrin bonded chiral stationary phases.
Book
The Impact of Stereochemistry on Drug Development and Use
TL;DR: Chirality and Drug Hazards Stereochemical Aspects of Drug Metabolism Some Examples of Stereoselective Biotransformation of Drugs Gastrointestinal Transport Processes Chiral Barbiturates-Synthesis, Chromatographic Resolutions, and Stereochemistry Integrity
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