Journal ArticleDOI
Optimization strategies for HPLC enantioseparation of racemic drugs using polysaccharides and macrocyclic glycopeptide antibiotic chiral stationary phases
Hassan Y. Aboul-Enein,Imran Ali +1 more
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TLDR
This review discusses the optimization of HPLC conditions for the chiral resolution of racemic drugs on polysaccharides and macrocyclic glycopeptide antibiotic chiral stationary phases (CSPs).Abstract:
The chiral resolution by high performance liquid chromatography (HPLC) is controlled by a number of parameters. The optimization of HPLC parameters is an important issue in chiral resolution. This review discusses the optimization of HPLC conditions for the chiral resolution of racemic drugs on polysaccharides and macrocyclic glycopeptide antibiotic chiral stationary phases (CSPs). The most important parameters discussed are composition of mobile phase, pH of mobile phase, flow rate, temperature and effect of other parameters.read more
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Health and environmental effects of persistent organic pollutants
TL;DR: In this paper, the authors describe the recent studies on the health and environmental problems due to pollution of persistent organic pollutants (POPs) and future prospectives, convention and regulation, control and removal measures of POPs have also been discussed.
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Chemical chiral pollution: Impact on the society and science and need of the regulations in the 21st century.
TL;DR: It is an urgent need of the present 21st century to develop a data bank on the chiral pollutants, guidelines for controlling the production, sale and use of the racemic agrochemicals and the other industrial products.
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Facile and eco-friendly synthesis of functionalized iron nanoparticles for cyanazine removal in water.
TL;DR: The removal method was quick, eco-friendly, and cheap owing to be appropriate under usual situations of water assets and can be applied for cyanazine removal in different waters.
Journal ArticleDOI
Effects of alcohol mobile-phase modifiers on the structure and chiral selectivity of amylose tris(3,5-dimethylphenylcarbamate) chiral stationary phase.
Tao Wang,Robert M. Wenslow +1 more
TL;DR: Solid-state NMR (1H/13C CPMAS) was utilized to identify and compare structural differences in Chiralpak AD caused by the various alcohol mobile-phase modifiers, many of which were not studied in the previous publication.
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Evaluation of generic chiral liquid chromatography screens for pharmaceutical analysis.
TL;DR: It is anticipated that the systematic use of the automated chiral HPLC screens described in this report will substantially reduce the necessary time for method development of pharmaceutically related chiral analytical methods.
References
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Journal ArticleDOI
Macrocyclic Antibiotics as a New Class of Chiral Selectors for Liquid Chromatography
TL;DR: In this article, three representative macrocyctic compounds were covalently linked to silica gel and evaluated by HPLC for their ability to resolve racemic mixtures as well as for their stability and loadability.
Book
A practical approach to chiral separations by liquid chromatography
TL;DR: In this article, an introduction to enantioseparation by liquid chromatography regulatory implications and chiral separations modelling enantiodifferentiation in chiral chromatography enantiomer separation using tailormade phases prepared by molecular imprinting cyclodextrin bonded chiral stationary phases.
Journal ArticleDOI
A covalently bonded teicoplanin chiral stationary phase for HPLC enantioseparations
TL;DR: It appears that teicoplanin is a widely applicable, highly effective chiral selector for HPLC enantioseparations.
Journal ArticleDOI
Chiral separations using the macrocyclic antibiotics: a review
Timothy J. Ward,Alton B. Farris +1 more
TL;DR: The macrocyclic antibiotics have recently gained popularity as chiral selectors in CE, HPLC and TLC and are complementary to one another, where if a partial enantioresolution is obtained with one glycopeptide, there is a high probability that a baseline or better separation can be obtained with another.
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