Histocytologic changes in grafts of rat pituitary on the kidney and upon retransplantation under the diencephalon.

TLDR: Histocytologic comparisons were made, by means of the periodic-acid Schiff (PAS) and the aldehyde fuchsin (AF) techniques, between pars distalis autografts on the kidney and similar grafts re-transplanted close to the median eminence.

Abstract: Histocytologic comparisons were made, hy means of the periodic-acid Schiff (PAS) and the aldehyde fuchsin (AF) techniques, between pars distalis autografts on the kidney and similar grafts re-transplanted close to the median eminence. Time intervals from transplantation to autopsy ranged from 1 day to 6 months. Transplants to the kidney are severely damaged by the transfer, the functional parenchyma ofthe established grafts apparently being derived from a thin shell of healthy tissue surroundingthe massive central infarct. Reorganization of the graft is essentially complete after 1 week. Normal cytologic differentiation is promptly lost. Large gonadotrophs (PAS+, AF−)are missing, but smaller ones may be found in significant numbers for 2 to 3 weeks; after thatthey are rarely recognized. Thyrotrophs (PAS +, AF+) are prominent during thefirst week, but older grafts usually contain in this category only a few minute, angular basophilesand occasional vacuolated cells thought to be “thyroidectomy cells.” Small...