Journal ArticleDOI
Homeostasis during hypoglycemia: central control of adrenal secretion and peripheral control of feeding
TLDR
While the sympathetic response during marked hypoglycemia may have been initiated by alterations in cerebal metabolism, the feeding response evidently was not, and a decrease in the utilization of glucose per se does not appear to be the critical stimulus in either case.Abstract:
Intravenous infusions of manose or B-hydroxybutyrate, metabolic fuels which can be oxidized by brain, abolished adrenal discharge of epinephrine in rats during insulin-induced hypoglycemia, whereas infusion of fructose, a sugar which does not cross the blood-brain barrier, did not. In contrast, increased feeding behavior during hypoglycemia was prevented both by the sugars and by B-hydroxybutyrate. Thus, while the sympathetic response during marked hypoglycemia may have been initiated by alterations in cerebal metabolism, the feeding response evidently was not, and a decrease in the utilization of glucose per se does not appear to be the critical stimulus in either case.read more
Citations
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Journal ArticleDOI
Metabolic fuels and reproduction in female mammals.
George N. Wade,Jill E. Schneider +1 more
TL;DR: Although there are species differences in the particular physiological and behavioral mechanisms mediating nutrition-reproduction interactions, two findings are consistent across species: 1) Reproductive physiology and behaviors are sensitive to the availability of oxidizable metabolic fuels and 2) When reproductive attempts are made, ovarian hormones play a major role in the changes in ingestion, partitioning, and utilization of metabolic fuels.
SYMPOSIUM: DRY MATTER INTAKE OF LACTATING DAIRY CATTLE Integration of Metabolism and Intake Regulation: A Review Focusing on Periparturient Animals
TL;DR: In this paper, the authors identified and discussed important metabolic factors involved in the regulation of dry matter intake in dairy cattle and their integration with metabolism, and discussed the adaptations of intake and metabolism and discussed mechanisms of intake regulation.
Journal ArticleDOI
The brain, appetite, and obesity
TL;DR: Food intake and energy expenditure are controlled by complex, redundant, and distributed neural systems that reflect the fundamental biological importance of adequate nutrient supply and energy balance.
Journal ArticleDOI
Integration of metabolism and intake regulation: a review focusing on periparturient animals.
TL;DR: Much research is needed to clarify the complex regulation of VDMI in lactating dairy cows, particularly in the periparturient animal, and evidence supporting the integration of the regulation of intake and metabolism is presented.
Journal ArticleDOI
Control of fertility by metabolic cues
TL;DR: The metabolic fuels hypothesis is consistent with a large body of evidence and seems to account for the infertility that is seen in a number of situations, including famine, eating disorders, excessive exercise, cold exposure, lactation, some types of obesity, and poorly controlled diabetes mellitus.
References
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Journal ArticleDOI
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
TL;DR: Saturability of D-glucose uptake was demonstrated and evidence presented that all of the five hexoses measurably taken up by brain shared a common carrier, two blood-brain barrier carrier systems for amino acids.
Journal ArticleDOI
Brain Metabolism during Fasting
TL;DR: Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation demonstrated that beta-hydroxybutyrate and acetoacetate replaced glucose as the predominant fuel for brain metabolism.
Journal ArticleDOI
Regulation of energy intake and the body weight: the glucostatic theory and the lipostatic hypothesis.
TL;DR: With the collaboration of Anliker, an experimental psychologist versed in the “Skinner box” techniques, the study of the probability of response to exposure to food and on the frequency of work for food of normal mice, as well as of littermates with the hereditary obese hyperglycemic syndrome, goldthioglucose obesity, and hypothalamic obesity is undertaken.
Journal ArticleDOI
Ketone-body utilization by adult and suckling rat brain in vivo
TL;DR: The results indicate that ketone bodies are major metabolic fuels of the brain of the suckling rat under normal conditions and are independent of the nutritional state.
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