Journal ArticleDOI
Hormonal control of mammalian spermatogenesis
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TLDR
Results from the studies indicate that changes in the metabolism of proteins lipids and carbohydrates take place in the testes under the control of hormones, but it may be that the observed biochemical changes are a reflection of the changes in cellular composition of testicular tissue rather than the result of metabolic changes within a specific cell type in response to the effect of a hormone.Abstract:
Studies of the hormonal control of the spermatogenic process are reviewed. Most of the investigations used the techniques of ablation and replacement therapy and were performed on the rat. Results from the studies indicate that changes in the metabolism of proteins lipids and carbohydrates take place in the testes under the control of hormones. However it may be that the observed biochemical changes which occur are a reflection of the changes in cellular composition of testicular tissue rather than the result of metabolic changes within a specific cell type in response to the effect of a hormone. A hypothesis concerned with the qualitative aspects of hormonal control of spermatogenesis in the rat has been formed. It is proposed that the multiplication and growth of gonocytes prenatally and in the first few days after birth and formation of type A spermatogonia are under the control of testosterone. The formation of type A and B spermatogonia and primary spermatocytes and progression of the meiotic prophase may be influenced by growth hormone. Reduction division is under control of testosterone. The early steps of spermatid formation may be under no hormonal control or may require testosterone while the late stages of spermatid maturation require the presence of FSH.read more
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Journal ArticleDOI
Cell Junction Dynamics in the Testis: Sertoli-Germ Cell Interactions and Male Contraceptive Development
C. Yan Cheng,Dolores D. Mruk +1 more
TL;DR: The physiology and biology of junction dynamics in the testis, in particular how these events affect interactions of Sertoli and germ cells in the seminiferous epithelium behind the blood-testis barrier are discussed.
Journal ArticleDOI
Men Homozygous for an Inactivating Mutation of the Follicle-Stimulating Hormone (FSH) Receptor Gene Present Variable Suppression of Spermatogenesis and Fertility
Juha S. Tapanainen,Kristiina Aittomäki,Kristiina Aittomäki,Jiang Min,Tommi E. Vaskivuo,Ilpo Huhtaniemi +5 more
TL;DR: It is demonstrated that FSH is more important for female than for male fertility, and questions the essential role of FSH for the initiation of spermatogenesis, and shows a clear-cut reduction in ligand binding and signal transduction by the mutated receptor.
Journal ArticleDOI
Degeneration of germ cells in normal, hypophysectomized and hormone treated hypophysectomized rats
Lonnie D. Russell,Yves Clermont +1 more
TL;DR: It appeared that the mid‐pachytene spermatocytes and the step 7 and 19 sperMatids were more sensitive to the presence of absence of gonadotropic hormones than the other germ cells present in the seminiferous epithelium.
Journal ArticleDOI
Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages
TL;DR: It is demonstrated that at least three factors determine the onset of apoptosis of the male germ cells: 1) the developmental stage of the animal; 2) serum levels of gonadotropins, especially FSH; and 3) specificStage of the seminiferous epithelial cycle.
Journal ArticleDOI
Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice.
TL;DR: It is concluded that androgens, acting through the androgen receptor without need for aromatization, initiate qualitatively complete spermatogenesis in the mouse, including fertile sperm despite low intratesticular androgen levels and the absence of blood FSH levels.
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