Journal ArticleDOI
Human muscle fiber fine structure: morphometric data on controls.
TLDR
Muscle fiber fine structure was quantitatively analyzed in 70 longitudinally and 65 transversely sectioned fibers from 10 control subjects without weakness and the feasibility of typing human muscle fibers at the ultrastructural level was evaluated.Abstract:
Muscle fiber fine structure was quantitatively analyzed in 70 longitudinally and 65 transversely sectioned fibers from 10 control subjects without weakness. The average mitochondrial fraction of the fiber volume is close to 4 percent and the mean size of a mitochondrion is about 0.1 μm 2 . The sarcotubular surface area per unit fiber volume is close to 1.5 μm 2 /μm 3 in transverse sections and 0.65 times this value in longitudinal sections. Only one-third of all fibers contain lipid droplets in the sectioned plane, and for all fibers the droplets account for approximately 0.12 percent of the fiber volume. Variations with the age and sex of the subjects and with different muscles were analyzed and the feasibility of typing human muscle fibers at the ultrastructural level was evaluated.read more
Citations
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Journal ArticleDOI
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
TL;DR: It is concluded that there is an impaired bioenergetic capacity of skeletal muscle mitochondria in type 2 diabetes, with some impairment also present in obesity.
Skeletal muscle adaptability : Significance for metabolism and performance
TL;DR: The sections in this article are: Fiber Composition in Human Skeletal Muscle, Motor Unit Recruitment, Adaptive Response, and Significance of Adaptation.
OtherDOI
Skeletal Muscle Adaptability: Significance for Metabolism and Performance
Bengt Saltin,Philip D. Gollnick +1 more
TL;DR: The sections in this article are:============\/\/\/\/\/\/£££1.11\/\/£2.10\/\/£3\/\/£4\/\/£5\/\/£6.1\/\/£7.2\/\/£8\/\/£9\/\/£10\/\/ £1.7\/\/£11.5\/\/ £2.9\/\/ £3£3£4£4 £6.2£5.3£7\/\/ £7.4£8£9.5£10.2 £7======
Journal ArticleDOI
Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases
TL;DR: Development of treatments for age-related and disease-related muscle loss might improve active life expectancy in older people, and lead to substantial health-care savings and improved quality of life.
Journal ArticleDOI
Intramyocellular lipid content in human skeletal muscle
Vera B. Schrauwen-Hinderling,Matthijs K. C. Hesselink,Patrick Schrauwen,ME Marianne Eline Kooi +3 more
TL;DR: IMCL quantification methods that use biopsy specimens (biochemical quantification, electron microscopy, and histochemistry) and non‐invasive alternatives (magnetic resonance spectroscopy, magnetic resonance imaging, and computed tomography) are reviewed.
References
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Journal ArticleDOI
Muscle Biopsy: A Modern Approach
TL;DR: This book deals with the muscle biopsy procedure, histochemical stains and reactions, and details of normal and pathologic changes of biopsied muscle, a beautiful integration of the clinical with the pathologic.
Journal ArticleDOI
A method for the quantitative estimation of cytoplasmic structures.
TL;DR: A sampling procedure and calculations are described by which electron micrographs of cytoplasmic structures may be quantitatively analyzed and a method for making a measurement of the quantity of endoplasmic reticulum or other membrane profiles is described.
Journal ArticleDOI
Stereological analysis of mammalian skeletal muscle. I. Soleus muscle of the adult guinea pig.
TL;DR: A quantitative analysis of the volumes, surface areas, and dimensions of the ultrastructural components in the soleus muscle fibers of the guinea pig was made by using point counting methods of stereology.
Journal ArticleDOI
Morphological effects of denervation of muscle. a quantitative ultrastructural study
TL;DR: The object of the present study was to provide morphometric data on normal and denervated muscle fiber fine structure on the basis of recent theories that propose a neurogenic mechanism iinderlying congenital and some acquired myopathies.