Journal ArticleDOI
Hyperhomocyst(e)inaemia: an independent risk factor for intermittent claudication.
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TLDR
The results suggest that folic acid supplementation should be tried in IC subjects with hyperhomocyst(e)inaemia, as it was independent of the other above‐mentioned risk factors.Abstract:
The aim of this study was to test the question of hyperhomocyst(e)inaemia as a risk factor for intermittent claudication (IC) independent of other important risk factors for peripheral atherosclerotic disease, such as smoking, hypertension, diabetes mellitus, hypercholesterolaemia, hypertriglyceridaemia, low levels of high-density-lipoprotein (HLD) cholesterol and age. The study population was recruited from an epidemiological study in Linkoping County, Sweden, where all middle-aged men (n = 15,253, 45-69 years of age) were screened for IC. Seventy-eight subjects with verified IC and 98 healthy sex- and age-matched controls were randomly selected. Plasma levels of homocyst(e)ine (including the sum of free and bound forms of homocysteine and their disulphide oxidation products, homocystine, and homocysteine-cysteine mixed disulphide) were significantly higher (16.74 +/- 5.45 mumol l-1, mean value +/- SD, P = 0.0002) in IC subjects than in controls (13.80 +/- 3.21 mumol l-1), with 23% of the claudicants above the 95th percentile for controls. Stepwise logistic regression analysis revealed that the difference in plasma homocyst(e)ine was independent of the other above-mentioned risk factors. Moreover, the elevation of plasma homocyst(e)ine in claudicants was mainly confined to subjects with serum folate levels of less than or equal to 11.0 nmol l-1. The results suggest that folic acid supplementation should be tried in IC subjects with hyperhomocyst(e)inaemia.read more
Citations
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Journal ArticleDOI
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
TL;DR: Higher folic acid intake by reducing tHcy levels promises to prevent arteriosclerotic vascular disease and under different assumptions, 13,500 to 50,000 CAD deaths annually could be avoided.
Journal ArticleDOI
ACC/AHA 2005 Practice Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic)
Alan T. Hirsch,Ziv J. Haskal,Norman R. Hertzer,Curtis W. Bakal,Mark A. Creager,Jonathan L. Halperin,Loren F. Hiratzka,William R.C. Murphy,Jeffrey W. Olin,Jules B. Puschett,Kenneth Rosenfield,David B. Sacks,James C. Stanley,Lloyd M. Taylor,Christopher J. White,John White,Rodney A. White,Elliott M. Antman,Sidney C. Smith,Cynthia D. Adams,Jeffrey L. Anderson,David P. Faxon,Valentin Fuster,Raymond J. Gibbons,Sharon A. Hunt,Alice K. Jacobs,Rick A. Nishimura,Joseph P. Ornato,Richard L. Page,Barbara Riegel +29 more
TL;DR: Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic) A Collaborative Report from the American Association for Vascular Surgery/Society for V vascular surgery,* Society for Cardiovascular Angiography and Interventions, Society forVascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines.
Journal ArticleDOI
Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study.
Ottar Nygård,S. E. Vollset,Helga Refsum,Inger Stensvold,Aage Tverdal,J E Nordrehaug,M Ueland,Gunnar Kvåle +7 more
TL;DR: Elevated plasma tHcy level was associated with major components of the cardiovascular risk profile, ie, male sex, old age, smoking, high blood pressure, elevated cholesterol level, and lack of exercise.
Journal ArticleDOI
Peripheral Arterial Disease in the Elderly The Rotterdam Study
Wouter T. Meijer,Arno W. Hoes,Dominique Rutgers,Michiel L. Bots,Albert Hofman,Diederick E. Grobbee +5 more
TL;DR: The authors conclude that the prevalence of PAD in the elderly is high whereas the prevalence in an elderly population is rather low, although both prevalences clearly increase with advancing age.
Journal ArticleDOI
Homocysteine and coronary atherosclerosis
TL;DR: Clinical and basic scientific evidence supporting the risk and mechanisms of vascular disease associated with elevated homocysteine concentrations are presented as well as the results of preliminary therapeutic trials.
References
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Journal ArticleDOI
Hyperhomocysteinemia: an independent risk factor for vascular disease.
Robert Clarke,Leslie Daly,Killian Robinson,E. R. Naughten,Seamus F. Cahalane,Brian Fowler,Ian D. Graham +6 more
TL;DR: Hyperhomocysteinemia is an independent risk factor for vascular disease, including coronary disease, and in most instances is probably due to cystathionine beta-synthase deficiency.
Journal ArticleDOI
Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection.
Atsushi Araki,Yoshiyasu Sako +1 more
TL;DR: A simple, sensitive and precise method for the determination of both free and total homocysteine in human plasma is presented.
Journal ArticleDOI
The prevalence of peripheral arterial disease in a defined population.
TL;DR: Assessment of large-vessel PAD prevalence by intermittent claudication dramatically underestimated the true large- Vessel P AD prevalence and assessment by peripheral pulse examination dramatically overestimated the true prevalence.
Journal ArticleDOI
Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.
TL;DR: It is concluded that homocystine-induced endothelial cell injury resulted in arteriosclerosis through platelet-mediated intimal proliferation of smooth muscle cells that can be prevented by drug-induced platelet dysfunction.
Journal ArticleDOI
Heterozygosity for Homocystinuria in Premature Peripheral and Cerebral Occlusive Arterial Disease
Godfried H.J. Boers,Antony G.H. Smals,Frans J.M. Trijbels,Brian Fowler,Jan A.J.M. Bakkeren,Henny C. Schoonderwaldt,Wim J. Kleijer,Peter W. C. Kloppenborg +7 more
TL;DR: It is concluded that this condition predisposes to the development of premature occlusive arterial disease, causing intermittent claudication, renovascular hypertension, and ischemic cerebrovascular disease.