Journal ArticleDOI
Hypochlorous acid as a precursor of free radicals in living systems
TLDR
This review discusses the reactions that occur between HOCl and the major classes of biologically important molecules to form free radicals to form reactive halogen species, which causes a number of socially important diseases.Abstract:
Hypochlorous acid (HOCl) is produced in the human body by the family of mammalian heme peroxidases, mainly by myeloperoxidase, which is secreted by neutrophils and monocytes at sites of inflammation. This review discusses the reactions that occur between HOCl and the major classes of biologically important molecules (amino acids, proteins, nucleotides, nucleic acids, carbohydrates, lipids, and inorganic substances) to form free radicals. The generation of such free radical intermediates by HOCl and other reactive halogen species is accompanied by the development of halogenative stress, which causes a number of socially important diseases, such as cardiovascular, neurodegenerative, infectious, and other diseases usually associated with inflammatory response and characterized by the appearance of biomarkers of myeloperoxidase and halogenative stress. Investigations aimed at elucidating the mechanisms regulating the activity of enzyme systems that are responsible for the production of reactive halogen species are a crucial step in opening possibilities for control of the development of the body’s inflammatory response.read more
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用FEV6.0代替FVC诊断气道阻塞和肺功能受限[英]/Swanney MP…∥Am J Respir Crit Care Med.
TL;DR: FVC测定:FVC� “�要测试者尽力呼出肺内气体,这一过程约需20sO老年人或有严重 肺疾病患者的体力常不堪�
Федеральное государственное бюджетное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний» Сибирского отделения Российской академии медицинских наук, Кемерово, Россия
S. V. Ivanov,A. N. Sumin,Y. V. Kazachek,D. E. Philipiev,S. M. Gusev,E. S. Malyshenko,L. S. Barbarash +6 more
TL;DR: The outcomes of CAD surgical treatment were improved in this group of patients due to the implementation of a mul-assisted revascularization of coronary and non-coronary arteries.
Journal ArticleDOI
Myeloperoxidase as an Active Disease Biomarker: Recent Biochemical and Pathological Perspectives
TL;DR: The enhanced level of MPO activity is one of the best diagnostic tools of inflammatory and oxidative stress biomarkers among these commonly-occurring diseases.
Journal ArticleDOI
Observations and impacts of bleach washing on indoor chlorine chemistry.
TL;DR: Photochemical box modeling indicates that the OH, Cl, and ClO gas-phase radical concentrations in the indoor environment could be greatly enhanced in such washing conditions, dependent on the amount of indoor illumination.
References
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Book
The Stress of Life
TL;DR: In this paper, the discovery of stress, the dissection of stress the disease of adaptation sketch for a unified theory implications and applications is described, and the authors propose a unified framework for adaptation.
Journal ArticleDOI
Tissue Destruction by Neutrophils
TL;DR: With increasing frequency, the human neutrophil is being implicated as a mediator of tissue-destructive events in inflammatory diseases ranging from rheumatoid arthritis and myocardial reperfusion injury to respiratory distress syndromes, blistering skin disorders, and ulcerative colitis.
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Myeloperoxidase: friend and foe
TL;DR: It is concluded that the MPO system plays an important role in the microbicidal activity of phagocytes and the role of theMPO system in tissue injury.