Journal ArticleDOI
Hypopigmentation in tinea versicolor: a histochemical and ectronmicroscopic study
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TLDR
The mechanism (s) which produce hypopigmentation in tinea versicolor infections has not been systematically studied, but the depigmentation of the genital area in Negro Jamaican babies secondary to tineaVersicolor infection, and the recent report of multiple hypopIGmented macules of tinea Versicolor on the shaft of the penis make this hypothesis unlikely.Abstract:
The mechanism (s) which produce hypopigmentation in tinea versicolor infections has not been systematically studied. It is generally considered that the fungus may filter ultraviolet light and prevent tanning of the infected area.i' 2 However, the depigmentation of the genital area in Negro Jamaican babies secondary to tinea versicolor infection,^ the recent report of multiple hypopigmented macules of tinea versicolor on the shaft of the penis'* and our clinical observation of sunburning limited to hypopigmented patches of tinea versicolor noted in Vietnam returnees make this hypothesis unlikely. Other theories which attempt to explain this phenomenon include failure in melanin granule transfer caused by increased keratinization,^ or a thinning of the stratum cornevun with subsequent loss of melanin granules contained within this legion.^ However, noread more
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Immunology of Diseases Associated with Malassezia Species
H. R. Ashbee,E. G. V. Evans +1 more
TL;DR: The finding that the genus Malassezia is immunomodulatory is important in understanding its ability to cause disease, and the lipid-rich layer around the yeast appears to be pivotal in this alteration of phenotype.
Journal ArticleDOI
Human infections due to Malassezia spp.
M J Marcon,D A Powell +1 more
TL;DR: Better understanding of how these organisms cause disease awaits the development of a useful typing scheme for epidemiologic studies and further studies on microbial virulence factors and the role of the immune response in pathogenesis.
Journal ArticleDOI
Identification of Tyrosinase Inhibitors in Cultures of Pityrosporum
M. Nazzaro-Porro,Siro Passi +1 more
TL;DR: Observations suggest that dicarboxylic acids could be used in the treatment of people with hyperpigmentary disorders by acting as competitive inhibitors of tyrosinase.
Journal ArticleDOI
Biology of hypopigmentation.
Jean L. Bolognia,John M. Pawelek +1 more
TL;DR: The proposed pathophysiology for each disorder of hypomelanosis is presented and the characteristics of several disorders of hypopigmentation are discussed.
References
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Journal ArticleDOI
HUMAN WOUND REPAIR: I. Epidermal Regeneration
George F. Odland,Russell Ross +1 more
TL;DR: Analysis of the submicroscopic cytology of differentiating and maturing regenerated epidermis reveals that, in the sequence of events, the formation of filaments, basal lamina, and desmosomes is followed chronologically by evolution of keratohyalin granules and, subsequently, by keratinization of the surface epidermal elements.
Journal ArticleDOI
Quantitative and Qualitative Data on the Pigment Cells of Adult Human Epidermis1
TL;DR: The morphology and physiology of the melanocyte have been studied thoroughly by numerous investigators, but conflicting statements concerning several basic points, and insufficient data concerning others were found in recent literature.
Journal ArticleDOI
Autoradiographic analysis of turnover times of normal and psoriatic epidermis.
TL;DR: A turnover time of approximately 30 days of pig epidermis was recently found by Weinstein (3) in an autoradiographic study utilizing both tritiated thymidine and glycine-C14 as nuclear and protein labels respectively.
Journal ArticleDOI
White leaf-shaped macules. Earliest visible sign of tuberous sclerosis
Thomas B. Fitzpatrick,George Szabo,Yoshiaki Hori,Andrew A. Simone,William B. Reed,Martin H. Greenberg +5 more
TL;DR: Cytologically altered melanocytes and decreased tyrosinase activity and reduced melanin deposition on melanosomes are present in the hypomelanotic macules of tuberous sclerosis, whereas melanocytes are very rarely present inThe hypomelsanotic Macules of vitiligo.
Journal ArticleDOI
Technique for Estimating Turnover Time of Human Stratum Corneum
Harvey Baker,Albert M. Kligman +1 more
TL;DR: The renewal time for the stratum corneum of the back was found to be about two weeks, for the back of the hand three weeks, and for the forehead one week, while the reduced forehead time may reflect a real increase in epidermal turnover rate at this site.
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