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Immunobiology: The Immune System in Health and Disease
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TLDR
Introductory immunology textbook for medical students, advanced undergraduates, and graduate students.Abstract:
Introductory immunology textbook for medical students, advanced undergraduates, and graduate students.read more
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Journal ArticleDOI
Microenvironmental regulation of metastasis
TL;DR: Experimental data demonstrating the role of the microenvironment in metastasis is described, areas for future research are identified and possible new therapeutic avenues are suggested.
Journal ArticleDOI
Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry
TL;DR: The present report meta-analyzes more than 300 empirical articles describing a relationship between psychological stress and parameters of the immune system in human participants to find that physical vulnerability as a function of age or disease also increased vulnerability to immune change during stressors.
Journal ArticleDOI
Learning and optimization using the clonal selection principle
L.N. de Castro,F.J. Von Zuben +1 more
TL;DR: This paper proposes a computational implementation of the clonal selection principle that explicitly takes into account the affinity maturation of the immune response and derives two versions of the algorithm, derived primarily to perform machine learning and pattern recognition tasks.
Patent
Polypeptide variants with altered effector function
TL;DR: In this article, the present invention concerns polypeptides comprising a variant of the Fc region, which have altered effector function as a consequence of one or more amino acid modifications in the region thereof.
Journal ArticleDOI
HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine.
Alexzander Asea,Stine-Kathrein Kraeft,Evelyn A. Kurt-Jones,Evelyn A. Kurt-Jones,Mary Ann Stevenson,Lan Bo Chen,Robert W. Finberg,Robert W. Finberg,Gloria C. Koo,Stuart K. Calderwood +9 more
TL;DR: Findings indicate that CD14 is a co-receptor for HSP70-mediated signaling in human monocytes and are indicative of an previously unrecognized function for H SP70 as an extracellular protein with regulatory effects on human monocyte, having a dual role as chaperone and cytokine.