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Important advances in oncology
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This article is published in Anti-Cancer Drugs.The article was published on 1991-08-01. It has received 728 citations till now.read more
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Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma
TL;DR: By comparing constitutional and tumour tissue genotypes of insulinomas from a pair of brothers who had inherited MEN-1 from their mother, it is shown that oncogenesis in these cases involves unmasking of a recessive mutation at this locus.
Journal ArticleDOI
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα
Asha Venkateswaran,Bryan A. Laffitte,Sean B. Joseph,Puiying A. Mak,Damien C. Wilpitz,Peter A. Edwards,Peter Tontonoz +6 more
TL;DR: The results indicate that cellular cholesterol efflux is controlled, at least in part, at the level of transcription by a nuclear receptor-signaling pathway, and suggest a model in which activation of LXRs by oxysterols in response to cellular sterol loading leads to induction of the ABCA1 transporter and the stimulation of lipid efflux to extracellular acceptors.
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Grafting of “Abbreviated” Complementarity-Determining Regions Containing Specificity-Determining Residues Essential for Ligand Contact to Engineer a Less Immunogenic Humanized Monoclonal Antibody
Roberto De Pascalis,Makoto Iwahashi,Midori Tamura,Eduardo A. Padlan,Noreen R. Gonzales,Ameurfina D. Santos,Mariateresa Giuliano,Peter Schuck,Jeffrey Schlom,Syed V. S. Kashmiri +9 more
TL;DR: The final variant of the HuCOL-1, which retains its Ag-binding reactivity and shows significantly lower serum reactivity than that of the parental Ab, can serve as a prototype for the development of a potentially useful clinical reagent.
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Impairment of Cognitive Function in Women Receiving Adjuvant Treatment for High-Risk Breast Cancer: High-Dose Versus Standard-Dose Chemotherapy
F.S.A.M. van Dam,Sanne B. Schagen,Martin J. Muller,Willem Boogerd,E. van der Wall,M.E. Droogleever Fortuyn,Sjoerd Rodenhuis +6 more
TL;DR: High-dose chemotherapy appears to impair cognitive functioning more than standard- dose chemotherapy, and central nervous system toxicity may be a dose-limiting factor in high-dose cancer treatment regimens.
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The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability.
TL;DR: This review addresses the progress to date on what is known about the role and regulation of drug efflux mechanisms in the intestine and liver.