Proceedings ArticleDOI
In vivo imaging of the development of linear and nonlinear retinal laser effects using optical coherence tomography in correlation with histopathological findings
Reginald Birngruber,Michael R. Hee,Stephen A. Boppart,James G. Fujimoto,Eric A. Swanson,Cynthia A. Toth,Cheryl Dawn DiCarlo,Clarence P. Cain,Gary D. Noojin,William P. Roach +9 more
- Vol. 2391, pp 21-27
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TLDR
A correlation between cross-sectional OCT-images and structural findings using classical histopathological techniques facilitates a better interpretation of the characteristic patterns seen in OCTimages and defines the sensitivity of the OCT-technique to image morphological details.Abstract:
Optical Coherence Tomography (OCT) is a new, non-invasive diagnostic technique for high resolution optical 3D imaging, which was developed and applied to several different biological materials during the lasi; five years [1, 2, 3]. A unique application ofthis technique is the microscopical cross-sectional imaging ofpostenor structures ofthe eye which are not accessable with other high resolution techniques in-vivo neither with x-ray-imaging nor with high frequency ultrasound scanning. The superior spatial resolution on the order ofabout lOtm laterally and axially, the high signal-to-noise ratio ofmore than 100 db and the fast acquisition-time of one second for a two dimensional scan provides a technique for cross-sectional in-vivo-momtoring ofintraocular structures and therefore the possibility to study the time course of anatomical and pathological developments in the eye. The acute morphological changes of ocular structures and their biological healing response after shortterm impacts such as high-intensity laser exposures are ofparticular interest for the understanding of the mechanisms responsible for therapeutic laser-application in ophthal-mology as well as for laser injury to the eye. A correlation between cross-sectional OCT-images and structural findings using classical histopathological techniques facilitates a better interpretation ofthe characteristic patterns seen in OCTimages and defines the sensitivity ofthe OCT-technique to image morphological details. On the other hand preparational artefacts not avoidable in all histological procedures can be identified and analyzed by comparing histological micrographs with OCT-images of exactly the same structure. First results of an experimental study where retinal effects were produced in monkey eyes using laser pulses from 200 ms to 130 fs in duration are presented in this article. The applied energies from 5tJ to 50 mJ were able to induce the whole spectrum of biological effects possible in the eye, ranging from intraretinal microruptures to extensive thermal denaturation and massive preretinal hemorrhages [4, 5, 6].read more
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Patent
Optical coherence tomographic system for ophthalmic surgery
TL;DR: In this paper, the authors proposed a method for imaging an eye relative to a Spectral Domain Optical Coherence Tomographic (SD-OCT) imaging system, the eye having a first and a second structure, and imaging the eye with the SDOCT imaging system by selecting one of a direct image and a mirror image of the first eye-structure and generating a first image-portion corresponding to the selected image.
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Optical system for ophthalmic surgical laser
Ferenc Raksi,Jesse Buck +1 more
TL;DR: In this article, a laser system for ophthalmic surgery includes a laser source to generate a pulsed laser beam, an XY scanner to output an XY-scanning beam, scanned in two directions transverse to a Z direction.
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Precise Targeting Of Surgical Photodisruption
TL;DR: Techniques, apparatus and systems for laser surgery including imaging-guided surgery techniques, apparatus, and systems are discussed in detail in this paper, where the authors present a survey of the latest advances in laser surgery.
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Imaging surgical target tissue by nonlinear scanning
TL;DR: In this paper, a method for guiding an eye surgery can include the steps of: positioning an eye in relation to an imaging system; creating first scan data by determining a depth of an eye target region at a first set of points along a first arc; creating second scan data, by determining the depth of the eye target regions at a second set of pixels along a second arc; determining target region parameters based on the first and second scans; and adjusting one or more surgical position parameters according to the determined target regions parameters.
Journal ArticleDOI
In situ monitoring of laser modification process in human cataractous lens and porcine cornea using coherence tomography
Vladislav A. Kamensky,Felix I. Feldchtein,Valentin M. Gelikonov,Ludmila B. Snopova,Sergey V. Muraviov,Aleksey Yu. Malyshev,Nikita Bityurin,Alexander M. Sergeev +7 more
TL;DR: It is demonstrated that optical coherence tomography (OCT) is a convenient diagnostic tool to monitor pulse-to-pulse kinetics in laser interactions with biological tissue and is accompanied by the probe beam shielding diagnostics to provide the time-resolved observation of the interaction dynamics.