In vivo Validation of 4D Flow MRI for Assessing the Hemodynamics of Portal Hypertension
Alejandro Roldán-Alzate,Alex Frydrychowicz,Eric Niespodzany,Ben Landgraf,Kevin M. Johnson,Oliver Wieben,Scott B. Reeder +6 more
TLDR
To implement and validate in vivo radial 4D flow MRI for quantification of blood flow in the hepatic arterial, portal venous, and splanchnic vasculature of healthy volunteers and patients with portal hypertension.Abstract:
Purpose:
To implement and validate in vivo radial 4D flow MRI for quantification of blood flow in the hepatic arterial, portal venous, and splanchnic vasculature of healthy volunteers and patients with portal hypertension.
Materials and Methods:
Seventeen patients with portal hypertension and seven subjects with no liver disease were included in this Health Insurance Portability and Accountability Act (HIPAA)-compliant and Institutional Review Board (IRB)-approved study. Exams were conducted at 3T using a 32-channel body coil with large volumetric coverage and 1.4 mm isotropic true spatial resolution. Using postprocessing software, cut-planes orthogonal to vessels were used to quantify flow (L/min) in the hepatic and splanchnic vasculature.
Results:
Flow quantification was successful in all cases. Portal vein and supraceliac aorta flow demonstrated high variability among patients. Measurements were validated indirectly using internal consistency at three different locations within the portal vein (error = 4.2 ± 3.9%) and conservation of mass at the portal confluence (error = 5.9 ± 2.5%) and portal bifurcation (error = 5.8 ± 3.1%).
Conclusion:
This work demonstrates the feasibility of radial 4D flow MRI to quantify flow in the hepatic and splanchnic vasculature. Flow results agreed well with data reported in the literature, and conservation of mass provided indirect validation of flow quantification. Flow in patients with portal hypertensions demonstrated high variability, with patterns and magnitude consistent with the hyperdynamic state that commonly occurs in portal hypertension. J. Magn. Reson. Imaging 2013;37:1100–1108. © 2012 Wiley Periodicals, Inc.read more
Citations
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Journal ArticleDOI
4D flow cardiovascular magnetic resonance consensus statement
Petter Dyverfeldt,Malenka M. Bissell,Alex J. Barker,Ann F. Bolger,Ann F. Bolger,Carl-Johan Carlhäll,Tino Ebbers,Christopher J. Francios,Alex Frydrychowicz,Julia Geiger,Daniel Giese,Michael D. Hope,Philip J. Kilner,Sebastian Kozerke,Saul G. Myerson,Stefan Neubauer,Oliver Wieben,Michael Markl +17 more
TL;DR: It is described that 4D Flow CMR can be clinically advantageous because placement of a single acquisition volume is straightforward and enables flow through any plane across it to be calculated retrospectively and with good accuracy.
Journal ArticleDOI
4D flow imaging with MRI
TL;DR: The purpose of this review is to describe the methods used for 4D flow MRI acquisition, post-processing and data analysis and provide an overview of the clinical applications of 4D Flow MRI, which includes a review of applications in the heart, thoracic aorta and hepatic system.
Journal ArticleDOI
Abdominal 4D Flow MR Imaging in a Breath Hold: Combination of Spiral Sampling and Dynamic Compressed Sensing for Highly Accelerated Acquisition
Hadrien A. Dyvorne,Ashley Knight-Greenfield,Guido H. Jajamovich,Cecilia Besa,Yong Cui,Aurélien F. Stalder,Michael Markl,Bachir Taouli +7 more
TL;DR: The combination of highly efficient spiral sampling with dynamic compressed sensing results in major acceleration for 4D flow MR imaging, which allows comprehensive assessment of abdominal vessel hemodynamics in a single breath hold.
Journal ArticleDOI
Four-dimensional Flow MRI: Principles and Cardiovascular Applications
Arshid Azarine,Philippe Garcon,A. Stansal,Nadia Canepa,Giorgios Angelopoulos,Stéphane Silvera,Daniel Sidi,Véronique Marteau,Marc Zins +8 more
TL;DR: The main technical issues of 4D flow MRI are reviewed and the main applications in cardiovascular diseases are described, including congenital heart disease, cardiac valvular disease, aortic disease, and pulmonary hypertension.
Journal ArticleDOI
Portal hypertension: Imaging of portosystemic collateral pathways and associated image-guided therapy
Murad Feroz Bandali,Anirudh Mirakhur,Edward Wolfgang Lee,Mollie Clarke Ferris,David J Sadler,Robin Gray,Jason K. Wong +6 more
TL;DR: The appearances and prevalence of both common and less common portosystemic collateral channels in the thorax and abdomen are discussed, which can be helpful for assessing overall prognosis and planning proper management.
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