Book ChapterDOI
Interactions between noradrenergic and cholinergic systems in the brain
H.C. Fibiger,S.T. Mason +1 more
- pp 1119-1121
TLDR
It is concluded that there exists a noradrenergic-cholinergic (muscarinic) interaction in the central nervous system which is involved in the control of motor activity.Abstract:
Catalepsy produced by the cholinergic (ACh) agonists, arecoline and pilocarpine, was blocked in rats in which the ascending noradrenergic (NA) projections had been selectively destroyed by intracerebral injections of 6-hydroxydopamine (6-OHDA). The same lesions potentiated the motor stimulant effects of the anticholinergic drugs, scopolamine and atropine. It is concluded that there exists a noradrenergic-cholinergic (muscarinic) interaction in the central nervous system which is involved in the control of motor activity.read more
References
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Sleep cycle control and cholinergic mechanisms: Differential effects of carbachol injections at pontine brain stem sites
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