Journal ArticleDOI
Intercellular junctions in the vascular stria and spiral ligament.
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TLDR
The junctional complexes in the vascular stria and spiral ligament of the chinchilla inner ear have been studied using the electron microscope with freeze-fracture technique and probably is connected with the unique ionic composition of the cochlear endolymph and with the maintenance of steep solute gradients by active transport in the stria.About:
This article is published in Journal of Ultrastructure Research.The article was published on 1975-12-01. It has received 101 citations till now. The article focuses on the topics: Tight junction & Spiral ligament.read more
Citations
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Journal ArticleDOI
Gap junctions in the rat cochlea: immunohistochemical and ultrastructural analysis.
TL;DR: The organization described here, together with a great deal of information from previous investigators, suggest that serially arranged gap junctions of both epithelial and connective tissue cells serve as the strucural basis for recycling endolymphatic potassium ions that pass through the sensory cells during the transduction process.
Journal ArticleDOI
K+ cycling and the endocochlear potential.
TL;DR: The importance of K+ cycling is underscored by the fact that mutations of KCNQ1, KCNE1,KCNQ4, GJB2,GJB3 and GJB6 lead to deafness in humans and that null mutations ofKCNZ1, Kansas City NE, KCNJ10 and SLC12A2 lead to hearing loss in mouse models.
Journal ArticleDOI
The fine structure of spiral ligament cells relates to ion return to the stria and varies with place-frequency
TL;DR: Analysis of cells in the cochlea's lateral wall was undertaken to investigate morophologic features relevant to the route of K+ cycling from organ of Corti to stria vascularis and to the question of a transcellular versus an extracellular path.
Book ChapterDOI
Structure of the Mammalian Cochlea
TL;DR: The cochlea within the inner ear contains the cells responsible for the perception of sound and is composed of a bony labyrinth, within which is found the cellular structures comprising the membranous labyrinth.
Journal ArticleDOI
Differentiation of inner ear fibrocytes according to their ion transport related activity.
TL;DR: Findings point to cooperativity in fluid and ion transport between epithelial cells and neighboring fibrocytes and demonstrate functional diversity of fibracytes of the inner ear providing a basis for classifying those in the spiral ligament.
References
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Journal ArticleDOI
Hexagonal array of subunits in intercellular junctions of the mouse heart and liver.
TL;DR: A new technique, based on the observations of Doggenweiler and Frenks, wMch has allowed us to demonstrate the presence of similar structures in sections of mouse heart and of mouse liver, and it seems likely that, as lanthanum solutions are brought to a high pH, a colloidal compound is formed which permeates the extracellular space as a tracer.
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Fracture faces of zonulae occludentes from "tight" and "leaky" epithelia
TL;DR: Epithelia of intermediate permeabilities exhibited junctions with intermediate or variable morphology, finding that the zonula occludens from a "very leaky" epithelium, the proximal convoluted tubule of the mouse kidney, is extremely shallow in the apical-basal direction, and consists of five or more interconnected junctional strands interposed between luminal and lateral membrane surfaces.
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Metabolic coupling, ionic coupling and cell contacts.
TL;DR: Observations using electron microscopy and freeze-etching techniques show that both metabolic coupling and ionic coupling in fibroblasts are associated with the appearance of “gap” junctions.
Journal ArticleDOI
Variations in tight and gap junctions in mammalian tissues.
TL;DR: The fine structure and distribution of tight and gap junctions in epithelia of the rat pancreas, liver, adrenal cortex, epididymis, and duodenum, and in smooth muscle were examined in paraformaldehyde-glutaraldehyde-fixed, tracer-permeated, and freeze-fractured tissue preparations.
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A fine structural analysis of intercellular junctions in the mouse liver.
TL;DR: Acetone does not cause any detectable change in the structure of the zonula occludens, but the occluding junction becomes leaky to lanthanum following acetone treatment, and the effects of other reagents on the junctions are reported.