Open Access
International Journal for Pharmaceutical Research Scholars (IJPRS)
TLDR
An attempt for developing a simple, aqueous and non aqueously based Bendamustine Hydrochloride, which is also being studied for the treatment of sarcoma.Abstract:
DNA Microarray is the emerging technique in Biotechnology. The many varieties of DNA microarray or DNA chip devices and systems are described along with their methods for fabrication and their use. It also includes screening and diagnostic applications. The DNA microarray hybridization applications include the important areas of gene expression analysis and genotyping for point mutations, single nucleotide polymorphisms (SNPs), and short tandem repeats (STRs). In addition to the many molecular biological and genomic research uses, this review covers applications of microarray devices and systems for pharmacogenomic research and drug discovery, infectious and genetic disease and cancer diagnostics, and forensic and genetic identification purposes.read more
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Pulsatile Drug Delivery System-A Review
Abhimanyu Rai Sharma,Binu Raina,Prabhjot Singh Bajwa,Anurag Bhargava,Toshiba Toshiba,Vrinda Goel +5 more
TL;DR: Pulsatile drug delivery systems (PDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease resulting in improved patient therapeutic efficacy and compliance as discussed by the authors.
Hollow Microspheres for Use as a Floating Controlled Drug Delivery System in the Stomach.
TL;DR: Hollow microspheres (microballoons), loaded with drug in their outer polymer shells, were prepared by a novel emulsion-solvent diffusion method and found to be partially or completely amorphous compared with the raw crystals of drug.
Journal Article
Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium
Kazufumi Nakamura,Kengo Kusano,Yoichi Nakamura,Hideki Fujio,Keiko Ohta,Katsumasa Miyaji,Satoshi Nagase,Hiroshi Morita,Katsushi Hashimoto,Mikio Kakishita,Tetsuro Emori,Hiromi Matsubara,Tohru Ohe +12 more
TL;DR: In this paper, the effect of carvedilol, a vasodilating &bgr;-blocker with antioxidant activity, on oxidative stress in human failing hearts has not been assessed.
Formulation and evaluation of floating in situ gelling system of losartan potassium
TL;DR: It was evident that formulation containing 2% of sodium alginate and 1.5% of Guar gum control the release of drug for longer duration and the drug release from the in situ gels follows the Fickian diffusion type of release.
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Antifungal Activity of Terminalia mantaly on the in vitro Growth of Cryptococcus neoformans
TL;DR: The traditional use of this plant for the treatment of fungal infections is justified and the hydro-alcoholic solvent (70% ethanol) followed by removal of oil is the best way to obtain an optimally concentrated extract.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
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Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge
TL;DR: A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented and comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99.
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A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
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Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
TL;DR: The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.